Chlordiazepoxide enhances the palatability of lithium-, amphetamine-, and saline-paired saccharin solution.

The ability of chlordiazepoxide to modify taste reactions elicited by a saccharin solution that was paired on three occasions with amphetamine (1 or 3 mg/kg), lithium (0.3 or 1.2 mEq/kg), or saline solution was assessed using the taste reactivity test. Chlordiazepoxide enhanced positive ingestive reactions regardless of the conditional properties of the tastant and had no effect on aversive reactions. These results support previous reports that chlordiazepoxide directly modifies the palatability of tastants.