Straub J P, van Kamp G J, van Maarsseveen T C, Stam J
Department of Clinical Chemistry, Free University Hospital, Amsterdam, The Netherlands.
Sarcoidosis. 1995 Mar;12(1):51-7.
Sarcoidosis can be presented to the physician as an active or silent disorder, which may resolve or lead to pulmonary fibrosis. Various serum or bronchoalveolar lavage fluid (BAL) markers have been suggested when trying to find one marker or a combination of markers which could be representative of the disease. The aim of the study was to evaluate a number of biochemical markers in comparison to cellular parameters in BAL of 45 patients with active or inactive sarcoidosis, as well as in 44 patients with other disorders and of 10 healthy volunteers. Moreover, in order to get insight into ACE activity in different compartments, ACE values in BAL and serum were compared. In active sarcoidosis BAL-procollagen-III-peptide was significantly increased in contrast to the very low values in inactive disease. In healthy volunteers procollagen-III-peptide levels were below the detection limit. In BAL no significant differences were found for beta-2-microglobulin, hyaluronan or ACE. Laminin in BAL was not detectable. Serum ACE, significantly enhanced in sarcoidosis, was not discriminative between active and inactive disease.
only procollagen-III-peptide in BAL was found to discriminate between active and inactive disease. Besides cell differentiation and T-helper/suppressor cell (CD4/CD8) ratio in BAL, no further biochemical parameters pointing to disease or activity of disease were found.
结节病可表现为活动性或隐匿性疾病，可能自行缓解或导致肺纤维化。在试图寻找一种或多种可代表该疾病的标志物时，人们提出了各种血清或支气管肺泡灌洗（BAL）液标志物。本研究的目的是评估45例活动性或非活动性结节病患者、44例其他疾病患者及10名健康志愿者BAL中的一些生化标志物，并与细胞参数进行比较。此外，为了解不同部位的血管紧张素转换酶（ACE）活性，对BAL和血清中的ACE值进行了比较。与非活动性疾病中极低的值相比，活动性结节病患者BAL中的前胶原III肽显著升高。健康志愿者的前胶原III肽水平低于检测限。BAL中的β2微球蛋白、透明质酸或ACE未发现显著差异。BAL中的层粘连蛋白无法检测到。结节病患者血清ACE显著升高，但在区分活动性和非活动性疾病方面无鉴别意义。
仅发现BAL中的前胶原III肽可区分活动性和非活动性疾病。除了BAL中的细胞分化和辅助性T细胞/抑制性T细胞（CD4/CD8）比值外，未发现其他指向疾病或疾病活动的生化参数。
