Vrzhesinskaia O A, Kodentsova V M, Kharitonchik L A, Alekseeva I A, Risnik V V, Spirichev V B
Vopr Med Khim. 1994 Nov-Dec;40(6):41-4.
The following patterns should be recommended as a criterion of normal vitamin B2 requirements: the FAD-effect is no more than 1.25, the levels of riboflavin, more than 5 ng/ml in the plasma and more than 130 ng/ml in the erythrocytes. At the same time, the hourly urinary riboflavin excretion more than 10 g/h may be used as a criterion of normal vitamin B2 requirements in children of 5-7 years old. These values were obtained while analysing the many-year experimental data on riboflavin treatment and using the mathematical analysis of the dependence curves for the urinary riboflavin excretion, its levels in plasma and erythrocytes, and the value of the FAD effect, as well as deriving and mathematically interpreting the variation curvers for the distribution of the given value of the FAD effect and the plasma riboflavin levels for human beings after additional vitamin therapy.
应推荐以下模式作为正常维生素B2需求量的标准:黄素腺嘌呤二核苷酸(FAD)效应不超过1.25,血浆中核黄素水平超过5 ng/ml,红细胞中超过130 ng/ml。同时,每小时尿核黄素排泄量超过10 μg/h可作为5至7岁儿童正常维生素B2需求量的标准。这些数值是在分析多年来核黄素治疗的实验数据,并对尿核黄素排泄量、其在血浆和红细胞中的水平以及FAD效应值的依赖曲线进行数学分析,以及推导和数学解释补充维生素治疗后人类FAD效应给定值和血浆核黄素水平分布的变化曲线时获得的。