LeRoith D, Baserga R, Helman L, Roberts C T
Molecular and Cellular Physiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Ann Intern Med. 1995 Jan 1;122(1):54-9. doi: 10.7326/0003-4819-122-1-199501010-00009.
The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.
胰岛素样生长因子（IGF）肽家族、结合蛋白和受体对人类正常生长发育至关重要，并参与大多数生理系统的特殊功能。IGF系统的大多数成员由不同的癌细胞表达，可能在这些恶性肿瘤的增殖中发挥重要作用。旨在调节IGF系统各种成分的新疗法可能会影响癌症的进展和转移。
