Ueno T, Tanaka A, Hamanaka Y, Suzuki T
Department of Surgery II, Yamaguchi University School of Medicine, Ube, Japan.
Br J Clin Pharmacol. 1995 Mar;39(3):330-2. doi: 10.1111/j.1365-2125.1995.tb04457.x.
Serum concentrations of paracetamol were measured at 30, 60, 120 and 180 min after oral administration of a solution of 1500 mg paracetamol in normal subjects (n = 32) (Group A) and in patients with total gastrectomy (Roux-en-Y reconstruction) (n = 5) (Group B), distal partial gastrectomy (Billroth I reconstruction) (n = 7) (Group C), pylorus preserving pancreatoduodenectomy (Billroth I type reconstruction) (n = 12) (Group D), and short bowel syndrome (n = 5) (Group E). In Group B, the dose was delivery directly into the jejunum 20 cm distal to the duodenojejunal flexure. The highest serum drug concentrations were observed in the 30 min sample in Groups B and C and in the 120 min sample in Groups A, D, and E. Mean (+/- s.d.) concentrations at these times were 18.90 +/- 1.55 micrograms ml-1 (Group B), 12.89 +/- 2.12 micrograms ml-1 (Group C), 11.12 +/- 3.16 micrograms ml-1 (Group A), 9.78 +/- 2.85 micrograms ml-1 (Group D), and 4.89 +/- 1.96 micrograms ml-1 (Group E), respectively. We conclude that in patients with normal intact gastrointestinal tract, most of a dose of oral paracetamol is absorbed from the jejunum distal to the duodenojejunal flexure.
在正常受试者（n = 32）（A组）以及全胃切除术（Roux-en-Y重建）患者（n = 5）（B组）、远端部分胃切除术（毕罗一世重建）患者（n = 7）（C组）、保留幽门的胰十二指肠切除术（毕罗一世型重建）患者（n = 12）（D组）和短肠综合征患者（n = 5）（E组）口服1500 mg对乙酰氨基酚溶液后30、60、120和180分钟测量血清对乙酰氨基酚浓度。在B组中，将剂量直接输送至十二指肠空肠曲远端20 cm处的空肠。在B组和C组的30分钟样本以及A组、D组和E组的120分钟样本中观察到最高血清药物浓度。这些时间的平均（±标准差）浓度分别为18.90±1.55μg/ml（B组）、12.89±2.12μg/ml（C组）、11.12±3.16μg/ml（A组）、9.78±2.85μg/ml（D组）和4.89±1.96μg/ml（E组）。我们得出结论，在胃肠道完整正常的患者中，口服对乙酰氨基酚的大部分剂量是从十二指肠空肠曲远端的空肠吸收的。
