Squire L R, Alvarez P
Department of Psychiatry, University of California (San Diego) School of Medicine, Veterans Affairs Medical Center, La Jolla, USA.
Curr Opin Neurobiol. 1995 Apr;5(2):169-77. doi: 10.1016/0959-4388(95)80023-9.
The fact that information acquired before the onset of amnesia can be lost (retrograde amnesia) has fascinated psychologists, biologists, and clinicians for over 100 years. Studies of retrograde amnesia have led to the concept of memory consolidation, whereby medial temporal lobe structures direct the gradual establishment of memory representations in neocortex. Recent theoretical accounts have inspired a simple neural network model that produces behavior consistent with experimental data and makes these ideas about memory consolidation more concrete. Recent physiological and anatomical findings provide important information about how memory consolidation might actually occur.
失忆症发作前获取的信息可能会丢失（逆行性失忆）这一事实，已经吸引心理学家、生物学家和临床医生长达100多年。对逆行性失忆的研究催生了记忆巩固的概念，即内侧颞叶结构引导新皮层中记忆表征的逐步建立。最近的理论解释激发了一个简单的神经网络模型，该模型产生的行为与实验数据一致，并使这些关于记忆巩固的观点更加具体。最近的生理学和解剖学发现为记忆巩固实际可能如何发生提供了重要信息。
