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利用反射傅里叶变换红外光谱对人脑垂体腺瘤蛋白质构象结构进行无损分析。

Non-destructive analysis of the protein conformational structure of human pituitary adenomas using reflectance FT-IR microspectroscopy.

作者信息

Lee L S, Lin S Y, Chi C W, Liu H C, Cheng C L

机构信息

Neurological Institute, Veterans General Hospital-Taipei, Taiwan, Republic of China.

出版信息

Cancer Lett. 1995 Jul 20;94(1):65-9. doi: 10.1016/0304-3835(95)03825-h.

DOI:10.1016/0304-3835(95)03825-h
PMID:7621446
Abstract

Reflectance Fourier-transform infrared microspectroscopy was used to determine the secondary structure and composition of the different human pituitary adenomas. Non-functioning pituitary adenomas exhibited similar protein secondary structure and conformational composition, but active pituitary adenomas revealed different behavior. The differences in secondary structure for the different human pituitary adenomas might possibly be due to the different protein conformations of the proliferated adenoma tissues and various hormones shared.

摘要

反射傅里叶变换红外显微光谱法用于确定不同人类垂体腺瘤的二级结构和组成。无功能性垂体腺瘤表现出相似的蛋白质二级结构和构象组成,但有活性的垂体腺瘤表现出不同的特征。不同人类垂体腺瘤二级结构的差异可能是由于增殖的腺瘤组织中不同的蛋白质构象以及所共有的各种激素所致。

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