Mkrtchian L N, Nersesian A K, Panosian A G
Genetika. 1995 May;31(5):729-31.
The anticlastogenic effect of the herbal preparation Loshtak on rats and mice was tested using the same scheme of treatment and doses of the preparation as are employed in medical practice. It was shown that intragastric administration of Loshtak results in a statistically significant decrease in the clastogenic effect of cyclophosphamide injected 48 h after the end of treatment with Loshtak. High doses of Loshtak did not induce any increase in the number of micronuclei in mouse bone marrow cells. Possible mechanisms responsible for the anticlastogenic effect of Loshtak are discussed.
使用与医学实践中相同的治疗方案和制剂剂量，对草药制剂Loshtak对大鼠和小鼠的抗致突变作用进行了测试。结果表明，在停止使用Loshtak治疗48小时后注射环磷酰胺，胃内给予Loshtak可使环磷酰胺的致突变作用在统计学上显著降低。高剂量的Loshtak并未导致小鼠骨髓细胞微核数量增加。文中讨论了Loshtak产生抗致突变作用的可能机制。
