al-Harbi M M, Qureshi S, Ahmed M M, Rafatullah S, Shah A H
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Am J Chin Med. 1994;22(1):77-82. doi: 10.1142/S0192415X94000103.
The anticlastogenic and biochemical potentials of Commiphora molmol were studied in Swiss albino mice treated with cyclophosphamide (CP). The C.molmol treatment (125-500 mg/kg) showed no mutagenicity. It caused a highly significant and dose-dependent mitodepressant effect in the femoral cells and reduction of RNA levels in hepatic cells as compared with the control. CP treatment showed significant increase in the frequency of micronuclei, cytotoxicity and reduction in the contents of nucleic acids and proteins. Pretreatment with C. molmol could neither alter the biochemical and cytological effects of CP nor show any additive effect of both treatments.
在经环磷酰胺（CP）处理的瑞士白化小鼠中研究了没药（Commiphora molmol）的抗致突变和生化潜力。没药处理（125 - 500毫克/千克）未显示出致突变性。与对照组相比，它在股骨细胞中引起了高度显著且剂量依赖性的有丝分裂抑制作用，并降低了肝细胞中的RNA水平。CP处理显示微核频率显著增加、细胞毒性以及核酸和蛋白质含量降低。用没药预处理既不能改变CP的生化和细胞学效应，也未显示出两种处理的任何相加效应。
