Salikhova R A, Dulatova Sh N, Poroshenko G G
Biull Eksp Biol Med. 1993 Apr;115(4):371-2.
The antimutagenic activity Angelica archangelica L. water and alcohol extracts thio-tepa against mutagenicity was investigated by the micronucleus test in mouse bone marrow and peripheral blood cells. The reduction of thio-tepa mutagenic activity was more prominent when the extracts were injected 2-hours before thio-tepa treatment as it could be seen at the simultaneous treatment. The observed reduction of micronucleus frequencies was up to 77%. No genotoxic effects of Angelica extracts had been seen at the concentrations 50-100 mg/kg.
通过小鼠骨髓和外周血细胞微核试验，研究了当归水提取物和乙醇提取物对硫代磷酸三乙酯致突变性的抗诱变活性。与同时处理相比，在硫代磷酸三乙酯处理前2小时注射提取物时，硫代磷酸三乙酯的诱变活性降低更为显著。观察到微核频率降低高达77%。在50-100mg/kg浓度下，未观察到当归提取物的遗传毒性作用。
