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适用于疫苗开发的重组破伤风毒素衍生物的特性分析。

Characterization of recombinant tetanus toxin derivatives suitable for vaccine development.

作者信息

Figueiredo D, Turcotte C, Frankel G, Li Y, Dolly O, Wilkin G, Marriott D, Fairweather N, Dougan G

机构信息

Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom.

出版信息

Infect Immun. 1995 Aug;63(8):3218-21. doi: 10.1128/iai.63.8.3218-3221.1995.

DOI:10.1128/iai.63.8.3218-3221.1995
PMID:7622252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173441/
Abstract

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

摘要

分离出破伤风毒素（TeTx）的重组衍生物并用于免疫小鼠。鉴定出重组TeTx轻链（一种已失去结合神经元能力的C片段衍生物）和一种能保护小鼠免受TeTx攻击的重组TeTx类毒素。

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本文引用的文献

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Production of biologically active light chain of tetanus toxin in Escherichia coli. Evidence for the importance of the C-terminal 16 amino acids for full biological activity.破伤风毒素生物活性轻链在大肠杆菌中的产生。C末端16个氨基酸对完全生物活性重要性的证据。
FEBS Lett. 1993 Jun 1;323(3):218-22. doi: 10.1016/0014-5793(93)81343-x.
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Characterization of the receptor-binding domain of tetanus toxin.破伤风毒素受体结合域的特性分析
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A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.破伤风毒素重组轻链中的单个突变消除了其蛋白水解活性，并消除了与天然重链重构后所见的毒性。
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4
Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides.破伤风毒素B片段和C片段与神经膜、甲状腺膜及神经节苷脂的相互作用。
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Isolation and characterization of Corynebacterium diphtheriae nontandem double lysogens hyperproducing CRM197.产CRM197的白喉棒状杆菌非串联双溶原菌的分离与鉴定
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The complete nucleotide sequence of tetanus toxin.破伤风毒素的完整核苷酸序列。
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Infect Immun. 1987 Nov;55(11):2541-5. doi: 10.1128/iai.55.11.2541-2545.1987.
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Oxygen dependence of omeprazole clearance and sulfone and sulfide metabolite formation in the isolated perfused rat liver.奥美拉唑清除率及砜和硫化物代谢产物形成在离体灌注大鼠肝脏中的氧依赖性
J Pharmacol Exp Ther. 1989 Sep;250(3):1043-7.
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Science. 1989 Oct 27;246(4929):497-500. doi: 10.1126/science.2683073.