适用于疫苗开发的重组破伤风毒素衍生物的特性分析。
Characterization of recombinant tetanus toxin derivatives suitable for vaccine development.
作者信息
Figueiredo D, Turcotte C, Frankel G, Li Y, Dolly O, Wilkin G, Marriott D, Fairweather N, Dougan G
机构信息
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom.
出版信息
Infect Immun. 1995 Aug;63(8):3218-21. doi: 10.1128/iai.63.8.3218-3221.1995.
Abstract
Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.
摘要
分离出破伤风毒素（TeTx）的重组衍生物并用于免疫小鼠。鉴定出重组TeTx轻链（一种已失去结合神经元能力的C片段衍生物）和一种能保护小鼠免受TeTx攻击的重组TeTx类毒素。
相似文献
1
Characterization of recombinant tetanus toxin derivatives suitable for vaccine development.适用于疫苗开发的重组破伤风毒素衍生物的特性分析。
Infect Immun. 1995 Aug;63(8):3218-21. doi: 10.1128/iai.63.8.3218-3221.1995.
2
Cell surface-exposed tetanus toxin fragment C produced by recombinant Bacillus anthracis protects against tetanus toxin.重组炭疽芽孢杆菌产生的细胞表面暴露破伤风毒素片段C可预防破伤风毒素。
Infect Immun. 1999 Sep;67(9):4847-50. doi: 10.1128/IAI.67.9.4847-4850.1999.
3
Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein.用产生百日咳毒素-破伤风毒素杂合蛋白的重组牛分枝杆菌卡介苗免疫的小鼠的体液免疫和细胞免疫反应
Infect Immun. 1999 Oct;67(10):5100-5. doi: 10.1128/IAI.67.10.5100-5105.1999.
4
Immunization of mice against tetanus with fragments of tetanus toxin synthesized in Escherichia coli.用在大肠杆菌中合成的破伤风毒素片段对小鼠进行破伤风免疫接种。
Infect Immun. 1987 Nov;55(11):2541-5. doi: 10.1128/iai.55.11.2541-2545.1987.
5
Sm14 of Schistosoma mansoni in fusion with tetanus toxin fragment C induces immunoprotection against tetanus and schistosomiasis in mice.曼氏血吸虫的Sm14与破伤风毒素片段C融合可诱导小鼠对破伤风和血吸虫病产生免疫保护。
Infect Immun. 2004 Oct;72(10):5931-7. doi: 10.1128/IAI.72.10.5931-5937.2004.
6
Lactobacilli as live vaccine delivery vectors: progress and prospects.乳酸杆菌作为活疫苗递送载体：进展与前景
Trends Biotechnol. 2002 Dec;20(12):508-15. doi: 10.1016/s0167-7799(02)02075-9.
7
Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908.百日咳毒素S1亚基-破伤风毒素片段C融合蛋白在伤寒疫苗株CVD 908中的表达及免疫原性
Infect Immun. 1996 Oct;64(10):4172-81. doi: 10.1128/iai.64.10.4172-4181.1996.
8
Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C.表达CRM197的牛分枝杆菌卡介苗对表达破伤风毒素片段C的卡介苗诱导的免疫反应的佐剂活性。
Vaccine. 2004 Jan 26;22(5-6):740-6. doi: 10.1016/j.vaccine.2003.08.017.
9
DeltaguaBA attenuated Shigella flexneri 2a strain CVD 1204 as a Shigella vaccine and as a live mucosal delivery system for fragment C of tetanus toxin.DeltaguaBA减毒福氏志贺菌2a菌株CVD 1204作为一种志贺菌疫苗以及破伤风毒素C片段的活黏膜递送系统。
Vaccine. 2000 Apr 28;18(21):2193-202. doi: 10.1016/s0264-410x(00)00025-6.
10
Immunization with recombinant Streptococcus gordonii expressing tetanus toxin fragment C confers protection from lethal challenge in mice.用表达破伤风毒素片段C的重组戈登链球菌免疫可使小鼠免受致死性攻击。
Vaccine. 2001 Feb 28;19(15-16):1931-9. doi: 10.1016/s0264-410x(00)00434-5.
引用本文的文献
1
Recent development of oral vaccines (Review).口服疫苗的最新进展（综述）
Exp Ther Med. 2024 Mar 22;27(5):223. doi: 10.3892/etm.2024.12511. eCollection 2024 May.
2
On-demand biomanufacturing of protective conjugate vaccines.保护性结合疫苗的按需生物制造
Sci Adv. 2021 Feb 3;7(6). doi: 10.1126/sciadv.abe9444. Print 2021 Feb.
3
Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy.抗原结构和组成设计以提高基于蛋白质的疫苗效力。
Front Immunol. 2020 Feb 24;11:283. doi: 10.3389/fimmu.2020.00283. eCollection 2020.
4
Tetanus toxin C-fragment: the courier and the cure?破伤风毒素 C 片段：载体与治疗？
Toxins (Basel). 2010 Nov;2(11):2622-44. doi: 10.3390/toxins2112622. Epub 2010 Oct 29.
5
Receptor and substrate interactions of clostridial neurotoxins.梭菌神经毒素的受体与底物相互作用
Toxicon. 2009 Oct;54(5):550-60. doi: 10.1016/j.toxicon.2008.12.027. Epub 2009 Mar 4.
6
Sm14 of Schistosoma mansoni in fusion with tetanus toxin fragment C induces immunoprotection against tetanus and schistosomiasis in mice.曼氏血吸虫的Sm14与破伤风毒素片段C融合可诱导小鼠对破伤风和血吸虫病产生免疫保护。
Infect Immun. 2004 Oct;72(10):5931-7. doi: 10.1128/IAI.72.10.5931-5937.2004.
7
Bacterial spores as vaccine vehicles.作为疫苗载体的细菌孢子。
Infect Immun. 2003 May;71(5):2810-8. doi: 10.1128/IAI.71.5.2810-2818.2003.
8
Expression of tetanus toxin Fragment C in tobacco chloroplasts.破伤风毒素C片段在烟草叶绿体中的表达。
Nucleic Acids Res. 2003 Feb 15;31(4):1174-9. doi: 10.1093/nar/gkg221.
9
Cell surface-exposed tetanus toxin fragment C produced by recombinant Bacillus anthracis protects against tetanus toxin.重组炭疽芽孢杆菌产生的细胞表面暴露破伤风毒素片段C可预防破伤风毒素。
Infect Immun. 1999 Sep;67(9):4847-50. doi: 10.1128/IAI.67.9.4847-4850.1999.
10
TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR.TetR是破伤风梭菌中破伤风毒素基因的正调控因子，与botR同源。
Infect Immun. 1998 Dec;66(12):5698-702. doi: 10.1128/IAI.66.12.5698-5702.1998.
本文引用的文献
1
Production of biologically active light chain of tetanus toxin in Escherichia coli. Evidence for the importance of the C-terminal 16 amino acids for full biological activity.破伤风毒素生物活性轻链在大肠杆菌中的产生。C末端16个氨基酸对完全生物活性重要性的证据。
FEBS Lett. 1993 Jun 1;323(3):218-22. doi: 10.1016/0014-5793(93)81343-x.
2
Characterization of the receptor-binding domain of tetanus toxin.破伤风毒素受体结合域的特性分析
J Biol Chem. 1993 May 25;268(15):11188-92.
3
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.破伤风毒素重组轻链中的单个突变消除了其蛋白水解活性，并消除了与天然重链重构后所见的毒性。
Biochemistry. 1994 Jun 7;33(22):7014-20. doi: 10.1021/bi00188a034.
4
Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides.破伤风毒素B片段和C片段与神经膜、甲状腺膜及神经节苷脂的相互作用。
J Biol Chem. 1980 Jul 10;255(13):6071-6.
5
Isolation and characterization of Corynebacterium diphtheriae nontandem double lysogens hyperproducing CRM197.产CRM197的白喉棒状杆菌非串联双溶原菌的分离与鉴定
Appl Environ Microbiol. 1983 Sep;46(3):560-4. doi: 10.1128/aem.46.3.560-564.1983.
6
The complete nucleotide sequence of tetanus toxin.破伤风毒素的完整核苷酸序列。
Nucleic Acids Res. 1986 Oct 10;14(19):7809-12. doi: 10.1093/nar/14.19.7809.
7
Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins.
EMBO J. 1986 Oct;5(10):2495-502. doi: 10.1002/j.1460-2075.1986.tb04527.x.
8
Immunization of mice against tetanus with fragments of tetanus toxin synthesized in Escherichia coli.用在大肠杆菌中合成的破伤风毒素片段对小鼠进行破伤风免疫接种。
Infect Immun. 1987 Nov;55(11):2541-5. doi: 10.1128/iai.55.11.2541-2545.1987.
9
Oxygen dependence of omeprazole clearance and sulfone and sulfide metabolite formation in the isolated perfused rat liver.奥美拉唑清除率及砜和硫化物代谢产物形成在离体灌注大鼠肝脏中的氧依赖性
J Pharmacol Exp Ther. 1989 Sep;250(3):1043-7.
10
Mutants of pertussis toxin suitable for vaccine development.适用于疫苗研发的百日咳毒素突变体。
Science. 1989 Oct 27;246(4929):497-500. doi: 10.1126/science.2683073.
Zotero 插件