Zdolsek B, Hellberg D, Fröman G, Nilsson S, Mårdh P A
Dept. of Obstetrics and Gynecology, Motala Hospital.
Infection. 1995 Mar-Apr;23(2):81-4. doi: 10.1007/BF01833870.
A history of recurrent vulvovaginal candidiasis (RVVC) was reported by 102 women, while current vulvovaginal candidiasis (VVC) was diagnosed in 83 of the same 996 women. They had all attended two family planning and one youth clinic, respectively. Two women, without RVVC or VVC, matched for age for each case of RVVC, were selected as a comparison group (COMP). Recurrent, but not current VVC, was associated with a history of sexually transmitted disease. Those with current, but not with recurrent, VVC had significantly more often genital warts and bacteriuria (> 10(5) bacteria/ml), but significantly less often bacterial vaginosis than the COMP women. Both VVC and RVVC were inversely correlated to a vaginal flora change with a mixed anaerobic vaginal flora. Those with VVC had a greater number of lactobacilli on vaginal cultures, than those with RVVC and the women in the COMP group. VVC and a history of RVVC both occurred more frequently in women with a lactobacilli-predominated vaginal flora, as compared with those with a flora change with a mixture of anaerobic and facultative anaerobic bacteria.
102名女性报告有复发性外阴阴道念珠菌病（RVVC）病史，而在这996名女性中的83名被诊断为患有当前外阴阴道念珠菌病（VVC）。她们分别去过两家计划生育诊所和一家青少年诊所。选取两名无RVVC或VVC且年龄与每例RVVC病例匹配的女性作为对照组（COMP）。复发性而非当前的VVC与性传播疾病史有关。患有当前而非复发性VVC的女性尖锐湿疣和菌尿（>10⁵细菌/毫升）的发生率明显更高，但细菌性阴道病的发生率明显低于对照组女性。VVC和RVVC均与阴道菌群变化及混合性厌氧阴道菌群呈负相关。患有VVC的女性阴道培养物中的乳酸杆菌数量比患有RVVC的女性和对照组女性更多。与具有厌氧和兼性厌氧细菌混合的菌群变化的女性相比，VVC和RVVC病史在以乳酸杆菌为主的阴道菌群的女性中更常见。
