Guadagnoli E, Hauptman P J, Ayanian J Z, Pashos C L, McNeil B J, Cleary P D
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA.
N Engl J Med. 1995 Aug 31;333(9):573-8. doi: 10.1056/NEJM199508313330908.
There are large geographic differences in the frequency with which coronary angiography and revascularization are performed. We attempted to assess whether differences in case mix or in the treatment of specific groups of patients may explain this variability. We also assessed the consequences of various patterns of treatment.
We studied patients covered by Medicare who were 65 to 79 years of age and were admitted to 478 hospitals with acute myocardial infarctions during 1990 in New York (1852 patients), where the rate of use of cardiac procedures is low, and in Texas (1837 patients), where the rate of use of such procedures is high. We compared the patterns of treatment of clinically similar groups of patients in the two states. We also compared mortality rates and measures of the health-related quality of life.
Coronary angiography was performed more often in Texas than in New York (45 percent vs. 30 percent, P < 0.001). The frequency of use in Texas was significantly higher than that in New York for all the clinical subgroups of patients analyzed except those at greatest risk for reinfarction. Over a two-year period, the adjusted likelihood of death was lower in New York than in Texas (hazard ratio, 0.87; 95 percent confidence interval, 0.78 to 0.98). Patients from Texas were 41 percent more likely to report angina (P = 0.002) and 62 percent more likely to say they could not perform activities requiring energy expenditure of 5 or more metabolic equivalents than patients from New York approximately two years after infarction (P < 0.001).
Physicians in Texas were more likely to perform angiography than physicians in New York for patients whose conditions allowed more discretion in the use of cardiac procedures. On average, there appears to be no advantage with respect to mortality or health-related quality of life to performing the procedures at the higher rate used in Texas.
冠状动脉造影和血运重建术的实施频率存在很大的地域差异。我们试图评估病例组合的差异或特定患者群体的治疗差异是否可以解释这种变异性。我们还评估了各种治疗模式的后果。
我们研究了医疗保险覆盖的65至79岁患者,这些患者在1990年因急性心肌梗死入住纽约的478家医院(1852例患者,该地心脏手术使用率较低)和得克萨斯州的478家医院(1837例患者,该地此类手术使用率较高)。我们比较了两个州临床相似患者群体的治疗模式。我们还比较了死亡率和与健康相关的生活质量指标。
得克萨斯州进行冠状动脉造影的频率高于纽约州(45%对30%,P<0.001)。除了再梗死风险最高的患者亚组外,在得克萨斯州分析的所有临床亚组患者中,手术使用率均显著高于纽约州。在两年期间,纽约州调整后的死亡可能性低于得克萨斯州(风险比,0.87;95%置信区间,0.78至0.98)。与纽约州的患者相比,得克萨斯州的患者在心肌梗死后约两年报告心绞痛的可能性高41%(P=0.002),表示无法进行需要5个或更多代谢当量能量消耗活动的可能性高62%(P<0.001)。
对于病情在心脏手术使用上允许更多自由裁量权的患者,得克萨斯州的医生比纽约州的医生更有可能进行血管造影。平均而言,以得克萨斯州较高的手术率进行手术在死亡率或与健康相关的生活质量方面似乎没有优势。