Bromm B, Scharein E, Darsow U, Ring J
Institute of Physiology, University Hospital Eppendorf, Hamburg, Germany.
Neurosci Lett. 1995 Mar 10;187(3):157-60. doi: 10.1016/0304-3940(95)11362-z.
The effects of cooling and topical application of menthol on histamine-induced itch, wheal and flare reactions of the left lower arm were investigated in a threefold cross-over design with 15 healthy male volunteers. Lowering skin temperature by cooling from 32.8 +/- 0.3 degrees C to 29.7 +/- 0.5 degrees C reduced itch intensity from 260 +/- 47 units to 55 +/- 12 units (visual analogue scale) and flare diameters from 39.0 +/- 2.0 mm to 30.2 +/- 1.8 mm; wheal reactions were not affected. A similar reduction in itch was found under menthol (42 +/- 14 units) although skin temperature was not decreased. These findings suggest a central inhibitory effect of cold sensitive A-delta fibre activation on itch.
采用三交叉设计，对15名健康男性志愿者研究了冷却和外用薄荷醇对组胺诱导的左下臂瘙痒、风团及潮红反应的影响。通过冷却将皮肤温度从32.8±0.3℃降至29.7±0.5℃，瘙痒强度从260±47单位降至55±12单位（视觉模拟评分），潮红直径从39.0±2.0mm降至30.2±1.8mm；风团反应未受影响。在使用薄荷醇的情况下（42±14单位）也发现瘙痒有类似程度的减轻，尽管皮肤温度并未降低。这些发现提示冷敏Aδ纤维激活对瘙痒具有中枢抑制作用。
