In vivo metabolism of aminopyrine by the larvae of the helminth Heligmosomoides polygyrus.
作者信息
Kerboeuf D, Soubieux D, Guilluy R, Brazier J L, Rivière J L
机构信息
Institut National de la Recherche Agronomique, Unité d'Helminthologie, Centre de Recherches de Tours, Nouzilly, France.
出版信息
Parasitol Res. 1995;81(4):302-4. doi: 10.1007/BF00931534.
PMID:7624287
Abstract
The in vivo N-dealkylation of [13C-2]-labeled aminopyrine by the L1-L2 larvae of Heligmosomoides polygyrus was demonstrated by the use of a sensitive gas chromatography-mass spectrometry method. This is the first evidence for the possible existence of a cytochrome P-450-dependent activity in helminths.
摘要
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