Santillo M, Rippa C, Della Morte R, Villani G R, Santangelo F, Staiano N, Mondola P
Istituto di Scienze Fisiologiche Umane, Facoltà di Medicina e Chirurgia, Università di Napoli Federico II, Italy.
Toxicol Lett. 1995 Aug;78(3):215-8. doi: 10.1016/0378-4274(95)03257-l.
The i.p. injection of the herbicide propanil to male Sprague-Dawley rats increased the susceptibility to lipoperoxidation of liver and brain rat microsomes. A liver damage produced by propanil treatment was demonstrated by decreased serum levels of cholesterol and triglycerides as compared to serum levels of the lipids in control rats. The cellular damage of rat liver was also confirmed by the increased serum levels of aspartate aminotransferase and alkaline phosphatase activities observed in propanil-treated rats as compared to their activities in control rats.
向雄性斯普拉格-道利大鼠腹腔注射除草剂敌稗，会增加大鼠肝脏和脑微粒体对脂质过氧化的敏感性。与对照大鼠的血脂水平相比，敌稗处理导致血清胆固醇和甘油三酯水平降低，证明了其对肝脏的损伤。与对照大鼠相比，在接受敌稗处理的大鼠中观察到天冬氨酸转氨酶和碱性磷酸酶活性的血清水平升高，这也证实了大鼠肝脏的细胞损伤。
