Sanner B, Konermann M, Sturm A
Medizinische Universitätsklinik der Ruhr-Universität Bochum Marienhospital I, Herne.
Z Kardiol. 1995 May;84(5):360-4.
Important pathophysiological mechanisms in obstructive sleep apnea at night are increasing pleural pressure swings, hypoxia and hypercapnia, as well as central nervous arousals with consecutive fragmentation of regular sleep structure. They influence the cardiovascular system, at first only at night and at a later stage also during the day. This might result in cardiac structural changes: dilation and hypertrophy of the right ventricle, hypertrophy of the left ventricle, (especially of the muscular ventricular septum), dilation of right and left atrium. It is suggested that these cardiac structural changes are characteristic for obstructive sleep apnea and therefore define the "sleep apnea heart".
夜间阻塞性睡眠呼吸暂停的重要病理生理机制包括胸膜压力波动增加、低氧血症和高碳酸血症，以及中枢神经觉醒伴规律睡眠结构的连续性破坏。它们首先仅在夜间影响心血管系统，随后在白天也会产生影响。这可能导致心脏结构改变：右心室扩张和肥厚、左心室肥厚（尤其是肌性室间隔）、左右心房扩张。有人认为这些心脏结构改变是阻塞性睡眠呼吸暂停的特征，因此定义了“睡眠呼吸暂停心脏”。
