绝经后女性前瞻性研究中的激素替代疗法与发病率和死亡率
Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women.
作者信息
Folsom A R, Mink P J, Sellers T A, Hong C P, Zheng W, Potter J D
机构信息
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
出版信息
Am J Public Health. 1995 Aug;85(8 Pt 1):1128-32. doi: 10.2105/ajph.85.8_pt_1.1128.
Abstract
We assessed the association of hormonal replacement therapy with mortality and incidence of multiple diseases in over 40,000 postmenopausal women followed for 6 years as part of the Iowa Women's Health Study. Compared with women who never used hormone replacement therapy, current users had multivariate adjusted relative risks (RR) as follows: total mortality (RR = 0.78; 95% confidence interval [CI] = 0.65, 0.94), coronary heart disease mortality (RR = 0.74; 95% CI = 0.48, 1.12), endometrial cancer incidence (RR = 4.3; 95% CI = 2.7, 6.9), breast cancer incidence (RR = 1.23; 95% CI = 0.99, 1.55), colon cancer incidence (RR = 0.72; 95% CI = 0.46, 1.12), and hip fracture incidence (RR = 0.53; 95% CI = 0.31, 0.91).
摘要
作为爱荷华州女性健康研究的一部分，我们对4万多名绝经后女性进行了为期6年的随访，评估了激素替代疗法与死亡率及多种疾病发病率之间的关联。与从未使用过激素替代疗法的女性相比，当前使用者经多变量调整后的相对风险（RR）如下：总死亡率（RR = 0.78；95%置信区间[CI] = 0.65，0.94），冠心病死亡率（RR = 0.74；95%CI = 0.48，1.12），子宫内膜癌发病率（RR = 4.3；95%CI = 2.7，6.9），乳腺癌发病率（RR = 1.23；95%CI = 0.99，1.55），结肠癌发病率（RR = 0.72；95%CI = 0.46，1.12），以及髋部骨折发病率（RR = 0.53；95%CI = 0.31，0.91）。
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