Lye M S, Ghazali A A, Mohan J, Alwin N, Nair R C
Division of Epidemiology and Biostatistics, Institute for Medical Research, Kuala Lumpur, Malaysia.
Am J Trop Med Hyg. 1995 Jul;53(1):68-72.
In October 1988, 13 Chinese children died of acute hepatic encephalopathy in the northwestern state of Perak in peninsular Malaysia. The acuteness of the illness differed from previously reported outbreaks described in Kenya, India, and Thailand. Epidemiologic investigations determined that the children had eaten a Chinese noodle, loh see fun, hours before they died. The attack rates among those who had eaten the noodles were significantly higher than those who had not (P < 0.0001). The cases were geographically scattered in six towns in two districts along the route of distribution of the noodle supplied by one factory in Kampar town. Aflatoxins were confirmed in postmortem samples from patients. This outbreak has important public health implications for many developing countries.
1988年10月，马来西亚半岛霹雳州西北部有13名中国儿童死于急性肝性脑病。这种疾病的急性程度与之前在肯尼亚、印度和泰国报道的疫情不同。流行病学调查确定，这些儿童在死亡前数小时食用了一种中式面条——loh see fun。食用面条者的发病率显著高于未食用者（P < 0.0001）。这些病例在地理上分布在甘榜镇一家工厂供应的面条分销路线沿线两个区的六个城镇。尸检样本中证实含有黄曲霉毒素。这次疫情对许多发展中国家具有重要的公共卫生意义。
