Chao T C, Maxwell S M, Wong S Y
Institute of Science and Forensic Medicine, Singapore.
J Pathol. 1991 Jul;164(3):225-33. doi: 10.1002/path.1711640307.
An outbreak of food poisoning resulting in 13 deaths in children occurred in Malaysia during the Chinese Festival of the Nine-Emperor Gods in 1988. The offending food was a Chinese noodle called 'Loh See Fun' (LSF). The source was traced to a factory where a banned food preservative was added to make the LSF. The food poisoning was attributable to aflatoxins and boric acid. The clinical features included vomiting, pyrexia, diarrhoea, abdominal pain, anorexia, giddiness, seizures, and eventual coma. Initially, many presented with a Reye-like syndrome. Eleven post-mortem examinations were performed. The pathological findings included extensive coagulative necrosis of the liver with proliferative 'ductal/ductular metaplasia of the hepatocytes'. Giant cell formation, central vein sclerosis, bile stasis, and steatosis were also noted. There was presence of acute tubular necrosis, superficial upper gastrointestinal erosions, and ensuing encephalopathy. The eventual cause of death is acute hepatic and renal failure.
1988年中国九皇爷节期间，马来西亚发生了一起导致13名儿童死亡的食物中毒事件。罪魁祸首食物是一种名为“卤细粉”（LSF）的中式面条。源头追溯到一家工厂，该厂为制作卤细粉添加了一种违禁食品防腐剂。此次食物中毒归因于黄曲霉毒素和硼酸。临床特征包括呕吐、发热、腹泻、腹痛、厌食、头晕、癫痫发作，最终昏迷。最初，许多患者表现出类似瑞氏综合征的症状。进行了11次尸检。病理结果包括肝脏广泛的凝固性坏死，伴有肝细胞的增生性“导管/小胆管化生”。还发现有巨细胞形成、中央静脉硬化、胆汁淤积和脂肪变性。存在急性肾小管坏死、浅表性上消化道糜烂以及随之而来的脑病。最终死因是急性肝肾功能衰竭。
