Hultberg B, Isaksson A, Nilsson J A, Lindgärde F
Department of Clinical Chemistry, University Hospital, Lund, Sweden.
Clin Chim Acta. 1994 Jun;227(1-2):59-68. doi: 10.1016/0009-8981(94)90135-x.
Lysosomes are involved in atherogenesis. Therefore we have studied the level of serum beta-hexosaminidase isoenzymes (Hex A and Hex B) in relation to risk factors for atherosclerosis in a homogeneous population of 886 post-menopausal women. We found a relation with several risk factors such as serum triglycerides, diastolic and systolic blood pressure, blood glucose, waist/hip ratio and body mass index but not with serum cholesterol. Also, the mean values for Hex A and Hex B were higher in smokers than in non-smokers but only the mean value for Hex A differed significantly. The relation of serum beta-hexosaminidase isoenzymes to risk factors might be due to lysosomal over-loading, which gives rise to increased enzyme synthesis and enhanced secretion of lysosomal enzymes to circulation. The subjects in the 95-100 percentile of Hex A showed significantly increased frequency of myocardial infarction of their fathers and of stroke in their mothers and the subjects in the 95-100 percentile of Hex B showed increased frequency of stroke in their mothers. Thus the findings of a relation between Hex isoenzymes and heredity for vascular disease further stress the significant relation between Hex isoenzymes and risk factors. Since Hex B is a sensitive marker for alcohol abuse, we also investigated its serum level in subjects that could be suspected of alcohol abuse. However, we did not find any differences in these subjects compared with the others, possibly due to the relatively short half-life of Hex B after alcohol withdrawal.
溶酶体与动脉粥样硬化的发生有关。因此，我们在886名绝经后女性的同质人群中，研究了血清β-己糖胺酶同工酶（Hex A和Hex B）水平与动脉粥样硬化危险因素之间的关系。我们发现它与几个危险因素有关，如血清甘油三酯、舒张压和收缩压、血糖、腰臀比和体重指数，但与血清胆固醇无关。此外，吸烟者中Hex A和Hex B的平均值高于不吸烟者，但只有Hex A的平均值有显著差异。血清β-己糖胺酶同工酶与危险因素之间的关系可能是由于溶酶体过载，这导致酶合成增加以及溶酶体酶向循环系统的分泌增强。Hex A处于第95 - 100百分位数的受试者，其父亲患心肌梗死和母亲患中风的频率显著增加；Hex B处于第95 - 100百分位数的受试者，其母亲患中风的频率增加。因此，己糖胺酶同工酶与血管疾病遗传之间关系的研究结果进一步强调了己糖胺酶同工酶与危险因素之间的显著关系。由于Hex B是酒精滥用的敏感标志物，我们还调查了可能涉嫌酒精滥用的受试者的血清水平。然而，与其他受试者相比，我们在这些受试者中未发现任何差异，这可能是由于戒酒之后Hex B的半衰期相对较短。
