Kärkkäinen P, Poikolainen K, Salaspuro M
Research Unit of Alcohol Diseases, University of Helsinki, Finland.
Alcohol Clin Exp Res. 1990 Apr;14(2):187-90. doi: 10.1111/j.1530-0277.1990.tb00469.x.
Beta-hexosaminidase, also called N-acetyl-beta-D-glucosaminidase, is a lysosomal glycosidase, which has been found to be increased in the sera of alcoholics admitted to acute detoxification treatment. To study serum beta-hexosaminidase (beta-HEX) as a marker of heavy drinking, it was compared with GGT, ASAT, and ALAT in three study groups: twenty-five drunken arrestees, 16 social drinkers, and 27 teetotallers. Mean serum beta-HEX levels were two times higher among drunken arrestees than among social drinkers or teetotallers. Average daily alcohol intake during the preceding 30 days in the pooled group of drunken arrestees and social drinkers correlated positively (r = 0.69; p less than 0.0001) with serum beta-HEX. The sensitivity of beta-HEX in the detection of heavy drinking, defined as over 60 g ethanol daily, was 85.7% compared to 47.6% for GGT. The specificity of beta-HEX was 97.6%. The positive correlations between beta-HEX and ASAT (r = 0.74; p less than 0.0001) and ALAT (r = 0.41; p less than 0.05) indicate that increased serum beta-HEX level may reflect early liver injury. Serum beta-HEX seems to be a sensitive biological marker of heavy drinking reflecting better the ingested amounts of alcohol than GGT.
β-己糖胺酶，也称为N-乙酰-β-D-氨基葡萄糖苷酶，是一种溶酶体糖苷酶，已发现其在接受急性脱毒治疗的酗酒者血清中含量升高。为了研究血清β-己糖胺酶（β-HEX）作为重度饮酒的标志物，将其与三组研究对象的谷氨酰转肽酶（GGT）、谷草转氨酶（ASAT）和谷丙转氨酶（ALAT）进行了比较：25名醉酒被捕者、16名社交饮酒者和27名戒酒者。醉酒被捕者的平均血清β-HEX水平是社交饮酒者或戒酒者的两倍。醉酒被捕者和社交饮酒者合并组在前30天的平均每日酒精摄入量与血清β-HEX呈正相关（r = 0.69；p < 0.0001）。β-HEX检测每日乙醇摄入量超过60克的重度饮酒的敏感性为85.7%，而GGT为47.6%。β-HEX的特异性为97.6%。β-HEX与ASAT（r = 0.74；p < 0.0001）和ALAT（r = 0.41；p < 0.05）之间的正相关表明血清β-HEX水平升高可能反映早期肝损伤。血清β-HEX似乎是重度饮酒的一个敏感生物学标志物，比GGT更能反映酒精摄入量。
