Harada K, Yura Y, Tsujimoto H, Kusaka J, Yoshida H, Sato M
Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Japan.
Eur J Cancer B Oral Oncol. 1995 Jan;31B(1):27-31. doi: 10.1016/0964-1955(94)00035-3.
The effect of local administration of epidermal growth factor (EGF) on 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced tumour formation was investigated in a hamster cheek pouch carcinogenesis model. DMBA-treated hamsters underwent either sialoadenectomy (groups 1 and 2) or a sham operation (groups 3 and 4). Thereafter, EGF (groups 1 and 3) or vehicle (groups 2 and 4) was applied to the cheek pouches for 6 weeks. Fourteen weeks after the beginning of the experiment, the number of cheek pouch tumours was significantly greater in EGF-treated hamsters than in vehicle-treated hamsters, irrespective of whether the submandibular glands had been removed. The number of forestomach tumours, induced by DMBA application to the cheek pouches, was also increased by EGF. These results suggest that EGF applied from the luminal side of the mucosa stimulates tumour formation in the hamster cheek pouch and forestomach.
在仓鼠颊囊致癌模型中，研究了局部给予表皮生长因子（EGF）对9,10 - 二甲基 - 1,2 - 苯并蒽（DMBA）诱导的肿瘤形成的影响。用DMBA处理的仓鼠接受了唾液腺切除术（第1组和第2组）或假手术（第3组和第4组）。此后，将EGF（第1组和第3组）或赋形剂（第2组和第4组）应用于颊囊6周。实验开始14周后，无论下颌下腺是否已被切除，接受EGF治疗的仓鼠颊囊肿瘤数量均显著多于接受赋形剂治疗的仓鼠。通过将DMBA应用于颊囊诱导的前胃肿瘤数量也因EGF而增加。这些结果表明，从粘膜腔侧施用的EGF会刺激仓鼠颊囊和前胃中的肿瘤形成。
