MacDonald D G, Critchlow H A
Int J Oral Maxillofac Surg. 1987 Feb;16(1):90-4. doi: 10.1016/s0901-5027(87)80035-8.
Hamster cheek pouches were treated with the topical carcinogen DMBA for 8 weeks. 2 episodes of cryosurgery, located within the area of previous carcinogen application enhanced the neoplastic process by comparison with matched controls. Comparison with previous studies suggests that the 2 episodes of cryosurgery may have a greater effect in provoking overt malignancy than a single episode of cryosurgery.
用局部致癌物二甲基苯并蒽（DMBA）处理仓鼠颊囊8周。与匹配的对照组相比，在先前涂抹致癌物的区域内进行2次冷冻手术，会加速肿瘤形成过程。与先前的研究相比表明，2次冷冻手术在引发明显恶性肿瘤方面可能比单次冷冻手术具有更大的影响。
