Ponce García J, Garrigues Gil V, Pertejo Pastor V, Valverde de la Osa J, Gálvez Castillo C, Berenguer Lapuerta J
Servicio de Medicina Digestiva, Hospital La Fe, Valencia.
Gastroenterol Hepatol. 1995 Jun-Jul;18(6):315-8.
The aim of this study was to analyze whether the vigorous character of esophageal contraction conditions differences in the clinical characteristics or in response to pneumatic dilatation treatment in patients with achalasia. To do so, a prospective protocol study was designed in which the clinical, radiological, and manometric characteristics of the patients and the response to pneumatic dilatation were compared on the basis of the presence or absence of severe contraction of the esophageal body. One hundred fifty-seven consecutive patients diagnosed with achalasia were included on presentation of a compatible clinical picture and absence of peristalsis in the esophageal body. Out of these patients, 120 presented a manometric pattern of typical achalasia and 37 had vigorous achalasia. Response to pneumatic dilatation was analyzed in 116 patients, 90 with typical achalasia and 26 with vigorous achalasia. Significant differences were only found between the two groups with respect to the greater response tone of the lower esophageal sphincter observed in the patients with vigorous achalasia. There were no differences in the remaining clinical, radiologic or manometric variables compared. Neither were any differences observed in regard to therapeutic response to pneumatic dilatation in the two groups of patients. It may be concluded that differentiation between typical and vigorous achalasia has no clinical or therapeutic significance.
本研究的目的是分析贲门失弛缓症患者食管收缩的强烈程度在临床特征或对气囊扩张治疗的反应方面是否存在差异。为此,设计了一项前瞻性方案研究,根据食管体部是否存在严重收缩,比较患者的临床、放射学和测压特征以及对气囊扩张的反应。157例连续诊断为贲门失弛缓症的患者因出现符合的临床表现且食管体部无蠕动而被纳入研究。在这些患者中,120例呈现典型贲门失弛缓症的测压模式,37例为强力型贲门失弛缓症。对116例患者进行了气囊扩张反应分析,其中90例为典型贲门失弛缓症,26例为强力型贲门失弛缓症。仅在两组之间发现,强力型贲门失弛缓症患者的食管下括约肌反应张力更大。在其余比较的临床、放射学或测压变量方面没有差异。两组患者在气囊扩张治疗反应方面也未观察到差异。可以得出结论,典型贲门失弛缓症和强力型贲门失弛缓症之间的区分没有临床或治疗意义。