Kitamura T, Yogo Y, Kunitake T, Suzuki K, Tajima A, Kawabe K
Department of Urology, Branch Hospital, Tokyo, Japan.
Int J Urol. 1994 Mar;1(1):28-32. doi: 10.1111/j.1442-2042.1994.tb00004.x.
Sixty-five renal allograft recipients on immunosuppressive therapy were examined for BK and JC viruria using Southern blot hybridization. The incidence and degree of BK and JC viruria were compared between this population (group RTR) and, an age- and sex-matched population of non-immunosuppressed individuals (group CTR). In the results, the incidence of BK viruria was significantly increased in the RTR group compared with the CTR group, while that of JC viruria was similar in the 2 groups. The proportion with a high level of JC viruria, however, was greater in the RTR group compared with the CTR group. Additionally, it was also demonstrated that the incidence of both BK and JC viruria was not affected by the characteristics of renal transplant recipients, such as differences in the donor source (living-related vs cadaveric), type of immunosuppressive agents used, or the time post-transplantation.
采用Southern印迹杂交法对65例接受免疫抑制治疗的肾移植受者进行BK病毒和JC病毒尿检测。比较了该人群（肾移植受者组，RTR组）与年龄和性别匹配的非免疫抑制个体人群（对照组，CTR组）中BK病毒和JC病毒尿的发生率及程度。结果显示，与CTR组相比，RTR组BK病毒尿的发生率显著升高，而两组JC病毒尿的发生率相似。然而，RTR组中JC病毒尿高水平的比例高于CTR组。此外，还表明BK病毒和JC病毒尿的发生率不受肾移植受者特征的影响，如供体来源（亲属活体供肾与尸体供肾）差异、所用免疫抑制剂类型或移植后时间。
