临床尸检率的下降是否减少了尸检对医学研究的贡献？
Have declining clinical necropsy rates reduced the contribution of necropsy to medical research?
作者信息
Start R D, Firth J A, Macgillivray F, Cross S S
机构信息
Department of Pathology, University of Sheffield Medical School.
出版信息
J Clin Pathol. 1995 May;48(5):402-4. doi: 10.1136/jcp.48.5.402.
AIMS
To examine trends in necropsy based research output for a period of 27 years during which there has been a progressive decline in clinical necropsy rates.
METHODS
The numbers of necropsy based research papers published between 1966 and 1993 were determined using the CD-Plus Medline computed literature database.
RESULTS
The number of necropsy based research papers containing necropsy or a synonym in the title increased by 220% between 1966 and 1993. When papers including necropsy or a synonym in the abstract, but not in the title, were included, the proportion of all indexed papers increased from 0.35% in 1975, when abstracts were first included, to 0.53% in 1993. Analysis of the subject material indicated that necropsy based research has constantly reflected trends and advances in clinical medicine. Neuroscience related research represented the largest subject category which may reflect the difficulties in obtaining human tissue from sources other than necropsy.
CONCLUSIONS
The modern necropsy continues to provide valuable information for all clinical and laboratory based disciplines. The decline in clinical necropsy rates would not yet appear to have undermined the contribution of the necropsy to research.
目的
研究在临床尸检率持续下降的27年期间基于尸检的研究产出趋势。
方法
利用CD-Plus Medline计算机文献数据库确定1966年至1993年间发表的基于尸检的研究论文数量。
结果
1966年至1993年间，标题中包含“尸检”或其同义词的基于尸检的研究论文数量增加了220%。当纳入摘要中包含“尸检”或其同义词但标题中未包含的论文时，所有索引论文的比例从1975年首次纳入摘要时的0.35%增至1993年的0.53%。对主题材料的分析表明，基于尸检的研究不断反映临床医学的趋势和进展。神经科学相关研究是最大的主题类别，这可能反映了从尸检以外的来源获取人体组织的困难。
结论
现代尸检继续为所有临床和实验室学科提供有价值的信息。临床尸检率的下降似乎尚未削弱尸检对研究的贡献。
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