Fantaskey A, Burkhart K K
Milton S. Hershey Medical Center, Pennsylvania State University, Central Pennsylvania Poison Center, Hershey, USA.
J Toxicol Clin Toxicol. 1995;33(4):359-61. doi: 10.3109/15563659509028923.
Venlafaxine hydrochloride is a novel bicyclic antidepressant which inhibits the reuptake of serotonin, norepinephrine and, to a lesser extent, dopamine. A 41-year-old female ingested 4.5 g venlafaxine, 500 mg diphenhydramine, 50 mg thiothixene and subsequently experienced severe central nervous system depression requiring intubation. She also developed elevated systolic and diastolic blood pressures and sinus tachycardia. The patient was decontaminated with gastric lavage and activated charcoal. She regained consciousness within a few hours and was extubated nine hours after ingestion. This case demonstrates that severe central nervous system depression may follow venlafaxine overdose.
盐酸文拉法辛是一种新型双环抗抑郁药，它可抑制5-羟色胺、去甲肾上腺素的再摄取，对多巴胺的再摄取抑制作用较弱。一名41岁女性摄入了4.5克文拉法辛、500毫克苯海拉明、50毫克硫利达嗪，随后出现严重的中枢神经系统抑制，需要插管治疗。她还出现了收缩压和舒张压升高以及窦性心动过速。该患者通过洗胃和活性炭进行了去污处理。她在数小时内恢复意识，并在摄入药物9小时后拔管。该病例表明，文拉法辛过量服用后可能会出现严重的中枢神经系统抑制。
