Abe S, Yoshimura H, Tabara H, Tachibana M, Monden N, Nakamura T, Nagaoka S
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
J Surg Oncol. 1995 Aug;59(4):226-9. doi: 10.1002/jso.2930590405.
Patients with stage T3N0-2M0 gastric carcinoma (n = 108) were studied for relevant prognostic factors. Peritoneal lavage cytology (PLC) was performed in all. In univariate analysis, 5-year survival rates were better with smaller serosal invasion (diameter < 3.0 cm vs. > or = 3.0 cm, 61% vs. 37%, P < 0.05) and fewer metastatic nodes (< or = 5 vs. > or = 6, 57% vs. 29%, P < 0.05). In multivariate analysis, only these two factors were significant. The predictive value of PLC was not shown in both univariate and multivariate analyses. Peritoneal recurrence occurred in 14 (22%) of 77 patients with negative PLC, and in 3 (18%) of 17 with positive PLC, the difference being not significant. Our results indicate that PLC is insensitive in predicting the development of peritoneal recurrence. Its role in the estimation of survival is limited, as many will die of visceral or locoregional recurrence if not of peritoneal dissemination.
对108例T3N0 - 2M0期胃癌患者进行了相关预后因素研究。所有患者均进行了腹腔灌洗细胞学检查（PLC）。单因素分析显示，浆膜侵犯范围较小（直径<3.0 cm与≥3.0 cm相比，5年生存率分别为61%和37%，P<0.05）以及转移淋巴结较少（≤5个与≥6个相比，5年生存率分别为57%和29%，P<0.05）的患者5年生存率更高。多因素分析显示，只有这两个因素具有显著性。单因素和多因素分析均未显示PLC的预测价值。77例PLC阴性患者中有14例（22%）发生腹膜复发，17例PLC阳性患者中有3例（18%）发生腹膜复发，差异无统计学意义。我们的结果表明，PLC在预测腹膜复发的发生方面不敏感。其在生存评估中的作用有限，因为许多患者即使不是死于腹膜播散，也会死于内脏或局部区域复发。
