所选合成化合物对鲁氏毛霉生长的影响。

Effects of selected synthetic compounds on growth of Mucor rouxii.

作者信息

Sabanero M, Rojas E, Torres V, Farfán N, Flores A, Contreras R

机构信息

Instituto de Investigación en Biología Experimental, Facultad de Química, Universidad de Guanajuato, Mexico.

出版信息

Microbios. 1995;82(332):173-80.

PMID:7630325

Abstract

The in vitro activity of four synthetic compounds was tested on fungal cells from Mucor rouxii. The compounds included phenylenediamine, two phenolamines, and quinone. At the concentrations tested (10(-2)-10(-4)M) the compounds exhibited antifungal activity, with the exception of quinone. On the basis of their effects on spore germination, and development of hyphae, phenylenediamine was the more active. The mechanism of action of the compounds is still unknown, but hyphae show morphological alterations and disturb the distribution of calcofluor in the cell wall. This suggests variations in the genesis of the cell wall.

摘要

测试了四种合成化合物对鲁氏毛霉真菌细胞的体外活性。这些化合物包括苯二胺、两种酚胺和醌。在所测试的浓度（10⁻² - 10⁻⁴M）下，除醌外，这些化合物均表现出抗真菌活性。基于它们对孢子萌发和菌丝发育的影响，苯二胺的活性更强。这些化合物的作用机制仍然未知，但菌丝显示出形态改变，并扰乱了细胞壁中荧光增白剂的分布。这表明细胞壁的形成存在变化。