Yamashita K, Kobayashi S, Kondo M, Ishikura H, Shibuya Y, Hayasaka S
Third Department of Internal Medicine, Shimane Medical University, Japan.
Ophthalmologica. 1995;209(3):172-5. doi: 10.1159/000310606.
We recently examined a patient with ophthalmic manifestations of Wegener's granulomatosis in whom antineutrophil cytoplasmic antibody (cANCA) titers provided helpful diagnostic information. A 40-year-old man who had suffered from bilateral exophthalmos for 9 months was diagnosed initially as having idiopathic inflammatory pseudotumor. The patient exhibited purulent nasal discharge and microhematuria. A histopathologic study revealed vasculitis. His ANCA titer for cANCA was found to be evaluated, and our patient was subsequently diagnosed as having Wegener's granulomatosis. His ocular symptoms resolved and did not recur after treatment with corticosteroid in combination with cyclophosphamide. We believe that cANCA levels should be investigated in patients with orbital pseudotumor as a possible sign of Wegener's granulomatosis.
我们最近检查了一名患有韦格纳肉芽肿眼部表现的患者，其抗中性粒细胞胞浆抗体（cANCA）滴度提供了有用的诊断信息。一名40岁男性，双侧眼球突出9个月，最初被诊断为特发性炎性假瘤。该患者出现脓性鼻分泌物和微量血尿。组织病理学研究显示血管炎。发现其cANCA的抗中性粒细胞胞浆抗体滴度得到评估，随后我们的患者被诊断为韦格纳肉芽肿。经皮质类固醇联合环磷酰胺治疗后，他的眼部症状消失且未复发。我们认为，对于眼眶假瘤患者应检测cANCA水平，以作为韦格纳肉芽肿的可能迹象。
