Kairemo K J, Kestilä M S, Svahn R I, Hiltunen J V
Abteilungen für Klinische Chemie, Universitätskrankenhaus Helsinki, Finnland.
Nuklearmedizin. 1995 Jun;34(3):115-7.
Ultrashort-lived tracer 191mIr (T1/2 = 4.92 s) can be obtained with a high yield from an 191Os/191mIr generator with a low 191Os breakthrough. It was eluated directly into the tail veins of Wistar rats. These animals were imaged dynamically (five frames/s) up to 40 s. The measurement was repeated five times on each animal. The whole-body retention and biodistribution of 191Os was studied by sacrificing the rats at one and four days, respectively, after injection. The activity retained was highest in the kidneys and the spleen, followed by the muscles and the liver. These values indicate that the breakthrough is by no means dangerous and that investigations can be repeated immediately with a radiation exposure of no significance. Furthermore, all investigations in the same animal were reproducible, suggesting that 191mIr might be a good tracer for nuclear angiograms.
超短寿命示踪剂191mIr（半衰期T1/2 = 4.92秒）可从191Os/191mIr发生器中以高产率获得，且191Os的突破率较低。它被直接洗脱到Wistar大鼠的尾静脉中。这些动物被动态成像（每秒5帧），持续40秒。对每只动物重复测量5次。分别在注射后1天和4天处死大鼠，研究191Os在体内的全身滞留和生物分布情况。滞留活性在肾脏和脾脏中最高，其次是肌肉和肝脏。这些数值表明这种突破绝无危险，并且可以在无显著辐射暴露的情况下立即重复进行研究。此外，在同一动物身上进行的所有研究都是可重复的，这表明191mIr可能是用于核血管造影的良好示踪剂。
