Vegesna V, McBride W H, Withers H R
Department of Radiation Oncology, University of California Los Angeles 90024-1714, USA.
Radiat Res. 1995 Aug;143(2):224-8.
Irradiation can complicate surgical wound healing, yet little is known of the importance of the time between surgery and irradiation on this process. This study investigated the impact of postoperative irradiation on gain in would tensile strength in a murine skin model. Irradiation on the same day as wounding or to 2-day-old wounds reduced wound tensile strength. In contrast, postoperative irradiation delivered at 7, 9 and 14 days transiently enhanced wound tensile strength, as measured 3 but not 4 or 5 weeks later. This effect was independent of the inclusion (hemibody) or exclusion (skin alone) of the hematopoietic system in the field of irradiation. Radiation-enhanced wound tensile strength was greater and occurred earlier after higher radiation doses. Even though the effect of irradiation in enhancing wound tensile strength is transitory, it could be important in assisting early wound healing.
放疗会使手术伤口愈合变得复杂，但对于手术与放疗之间的时间间隔对这一过程的重要性却知之甚少。本研究在小鼠皮肤模型中调查了术后放疗对伤口抗张强度增加的影响。在伤口形成当天或对形成2天的伤口进行放疗会降低伤口抗张强度。相比之下，在术后第7、9和14天进行放疗，在3周而非4周或5周后测量时，会短暂提高伤口抗张强度。这种效应与放疗区域内造血系统的纳入（半身）或排除（仅皮肤）无关。更高的放疗剂量后，放疗增强的伤口抗张强度更大且出现得更早。尽管放疗增强伤口抗张强度的效应是暂时的，但它在协助早期伤口愈合方面可能很重要。
