Le(a)和Le(b)组织糖鞘脂
Le(a) and Le(b) tissue glycosphingolipids.
作者信息
Hauser R
机构信息
Department of Forensic Medicine, Gdansk Medical School, Poland.
出版信息
Transfusion. 1995 Jul;35(7):577-81. doi: 10.1046/j.1537-2995.1995.35795357880.x.
BACKGROUND
The Le(a) and Le(b) antigens are synthesized by cells making exocrine secretions, but it is not well-defined where plasma and red cell Le(a) and Le(b) antigens are made.
STUDY DESIGN AND METHODS
This study uses chromatographic and immunochemical methods to extract Le(a) and Le(b) glycolipids from human tissues.
RESULTS
Le(a) and Le(b) antigens may be synthesized by both epithelial and mesodermal tissues. Expression of Lewis transferase activity was demonstrated in various tissues, confirming the epistatic interaction by Le and H genes to form the Leb antigen.
CONCLUSION
The Le(a) and Le(b) substances found in plasma might originate from the epithelial cells of the digestive tract.
背景
Le(a)和Le(b)抗原由产生外分泌液的细胞合成，但血浆和红细胞Le(a)及Le(b)抗原的合成部位尚不清楚。
研究设计与方法
本研究采用色谱法和免疫化学方法从人体组织中提取Le(a)和Le(b)糖脂。
结果
Le(a)和Le(b)抗原可能由上皮组织和中胚层组织合成。在多种组织中均证实有Lewis转移酶活性的表达，证实了Le和H基因的上位相互作用以形成Leb抗原。
结论
血浆中发现的Le(a)和Le(b)物质可能源自消化道的上皮细胞。
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