Rosenstein E D, Eskow R N, Lederman D A, Kramer N
Arthritis and Rheumatic Disease Center, St. Barnabas Medical Center, Livingston, New Jersey 07039, USA.
Am J Med Sci. 1995 Aug;310(2):65-7. doi: 10.1097/00000441-199508000-00005.
The authors describe a 22-year-old man with osteolytic mandibular and maxillary lesions. Biopsy substantiated the presence of Langerhans cell histiocytosis (eosinophilic granuloma). Levels of serum angiotensin-converting enzyme (ACE) were elevated repeatedly. After definitive therapy with excision and bone grafting, ACE levels returned to normal. The role of histiocytes in ACE production is discussed. Langerhans cell histiocytosis should be considered in the diagnosis of conditions occurring with elevation of serum ACE levels and clinical findings similar to sarcoidosis.
作者描述了一名22岁患有下颌骨和上颌骨溶骨性病变的男性。活检证实存在朗格汉斯细胞组织细胞增多症（嗜酸性肉芽肿）。血清血管紧张素转换酶（ACE）水平反复升高。在进行切除和骨移植的确定性治疗后，ACE水平恢复正常。文中讨论了组织细胞在ACE产生中的作用。在诊断血清ACE水平升高且临床表现类似于结节病的疾病时，应考虑朗格汉斯细胞组织细胞增多症。
