Campbell S S, Dijk D J, Boulos Z, Eastman C I, Lewy A J, Terman M
Laboratory of Human Chronobiology, New York Hospital, Cornell University Medical College, White Plains, NY 10605, USA.
J Biol Rhythms. 1995 Jun;10(2):129-32. doi: 10.1177/074873049501000205.
In addition to the well-established phase-shifting properties of timed exposure to bright light, some investigators have reported an acute alerting, or activating, effect of bright light exposure. To the extent that bright light interventions for sleep disturbance may cause subjective and/or central nervous system activation, such a property may adversely affect the efficacy of treatment. Data obtained from patient samples and from healthy subjects generally support the notion that exposure to bright light may be associated with enhanced subjective alertness, and there is limited evidence of objective changes (EEG, skin conductance levels) that are consistent with true physiological arousal. Such activation appears to be quite transient, and there is little evidence to suggest that bright light-induced activation interferes with subsequent sleep onset. Some depressed patients, however, have experienced insomnia and hypomanic activation following bright-light exposure.
除了定时暴露于强光下已明确的相位转移特性外,一些研究人员还报告了强光暴露具有急性警觉或激活作用。就用于睡眠障碍的强光干预可能导致主观和/或中枢神经系统激活而言,这种特性可能会对治疗效果产生不利影响。从患者样本和健康受试者获得的数据总体上支持这样一种观点,即暴露于强光可能与主观警觉性增强有关,并且与真正的生理唤醒一致的客观变化(脑电图、皮肤电导水平)的证据有限。这种激活似乎相当短暂,几乎没有证据表明强光诱导的激活会干扰随后的入睡。然而,一些抑郁症患者在强光暴露后出现了失眠和轻躁狂激活。