HLA-Dw3相关B细胞同种异体抗原-DRw3与乳糜泻之间存在强关联。

Strong association between the HLA-Dw3-related B cell alloantigen -DRw3 and coeliac disease.

作者信息

Ek J, Albrechtsen D, Solheim B G, Thorsby E

出版信息

Scand J Gastroenterol. 1978;13(2):229-33. doi: 10.3109/00365527809181753.

Abstract

The frequency of HLA-A, -B, and -C antigens, of -DRw3 and the associated B-lymphocyte alloantigen -DRw3 has been studied in 68 children with coeliac disease (CD). CD was found to be primarily associated with the B-lymphocyte alloantigen, the relative risk being calculated to 54. The possible relation between the B-lymphocyte alloantigen DRw3 and -Dw3 is discussed. The high relative risk and the fact that 95% of the patients with probable or definite CD had the B-lymphocyte alloantigen DRw3, underline the diagnostic value of B-lymphocyte typing in coeliac disease.

摘要

我们对68例乳糜泻（CD）患儿的HLA - A、- B和 - C抗原、- DRw3以及相关的B淋巴细胞同种抗原 - DRw3的频率进行了研究。发现乳糜泻主要与B淋巴细胞同种抗原相关，计算出的相对风险为54。文中讨论了B淋巴细胞同种抗原DRw3与 - Dw3之间的可能关系。较高的相对风险以及95%可能或确诊的乳糜泻患者具有B淋巴细胞同种抗原DRw3这一事实，突显了B淋巴细胞分型在乳糜泻诊断中的价值。