成人乳糜泻与HLA-DRw3和-DRw7相关。
Adult celiac disease associated with HLA-DRw3 and -DRw7.
作者信息
Betuel H, Gebuhrer L, Descos L, Percebois H, Minaire Y, Bertrand J
出版信息
Tissue Antigens. 1980 Mar;15(3):231-8. doi: 10.1111/j.1399-0039.1980.tb00912.x.
Celiac disease (CD), which occurs in Europe with varying frequency, is known to be associated with HLA-B8 and even more strongly with HLA-Dw3 because of the high linkage disequilibrium between these two antigens. After typing for HLA-A, -B and -DR antigens in adult patients with CD, we can confirm the high prevalence of B8 (72.7%) and of DRw3 (63.7%). However we find that DRw7 is also significantly increased (54.5%); DRw3 and DRw7, taken together, represent 86% of our 22 patients.
乳糜泻（CD）在欧洲的发病率各不相同，已知其与HLA - B8相关，由于这两种抗原之间存在高度连锁不平衡，所以与HLA - Dw3的关联更强。在对成年乳糜泻患者进行HLA - A、- B和 - DR抗原分型后，我们可以确认B8（72.7%）和DRw3（63.7%）的高患病率。然而，我们发现DRw7也显著增加（54.5%）；在我们的22名患者中，DRw3和DRw7合计占86%。
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