Ricciotti H A, Chen K T, Sachs B P
Department of Obstetrics and Gynecology, Beth Israel Hospital, Boston, MA, USA.
Future Child. 1995 Spring;5(1):71-86.
Technology plays an important role in the practice of medicine, and it is essential that controlled clinical trials be conducted before new technologies are widely disseminated. In this article, information from the medical literature is summarized and critiqued for several common obstetric technologies which are aimed at reducing the incidence or sequelae of low birth weight and preterm birth. These technologies include home uterine activity monitoring, tocolytic drugs to suppress uterine contractions, corticosteriods to accelerate fetal lung maturity, bed rest to prevent preterm delivery, delivery methods, multifetal pregnancy reduction, and cervical cerclage. A major challenge to the practice of medicine is to find effective ways to modify physician behavior to encourage the use of proven, effective technologies, and discourage the use of unproven, ineffective technologies. Despite widespread use, most obstetrical technologies appear to have had little impact on reducing the incidence of low birth weight or preterm births, as rates of low birth weight and preterm birth have not decreased appreciably in the past 25 years. Uncovering the basic mechanisms responsible for the onset of preterm labor will undoubtedly facilitate the discovery of new technologies to prevent low birth weight and preterm births.
技术在医学实践中发挥着重要作用,在新技术广泛传播之前进行对照临床试验至关重要。在本文中,我们总结并评析了医学文献中关于几种常见产科技术的信息,这些技术旨在降低低体重儿和早产的发生率或后遗症。这些技术包括家庭子宫活动监测、抑制子宫收缩的宫缩抑制剂、加速胎儿肺成熟的皮质类固醇、预防早产的卧床休息、分娩方式、多胎妊娠减胎术以及宫颈环扎术。医学实践面临的一个重大挑战是找到有效的方法来改变医生的行为,鼓励使用经过验证的有效技术,同时不鼓励使用未经证实的无效技术。尽管这些产科技术被广泛使用,但在过去25年里,低体重儿和早产的发生率并未明显下降,这表明大多数产科技术似乎对降低低体重儿和早产的发生率影响不大。揭示早产发生的基本机制无疑将有助于发现预防低体重儿和早产的新技术。