Athanasiou K A, Agarwal A, Muffoletto A, Dzida F J, Constantinides G, Clem M
Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78284-7774, USA.
Clin Orthop Relat Res. 1995 Jul(316):254-66.
The material properties of normal adult articular cartilage were determined in the femoral head and acetabulum of baboons, dogs, and bovines, and were compared with those of normal human hip cartilage. In situ creep and recovery indentation experiments were performed using an automated creep indentation apparatus. To curvefit the entire creep curve, a numerical algorithm based on biphasic finite element methods and nonlinear optimization was developed. This effort represents the first successful use of 100% of the creep indentation curve to obtain the mechanical properties of normal articular cartilage. The results show that material properties of articular cartilage exhibit significant topographical variations in the femoral head and acetabulum, and between these two bone structures. Furthermore, significant differences exist in the mechanical properties of hip cartilage among the 4 species. Specifically, in all species the smallest aggregate modulus is found in the inferior aspect of the femoral head. Among all species, human hip cartilage is the stiffest in all test sites; bovine tissue is the softest. Human tissue has the smallest Poisson's ratio and permeability in all test sites. The aggregate modulus of human hip cartilage is closely resembled by that of baboon hip cartilage. Anatomically, canine and baboon hips exhibit similar characteristics to the human hip joint; the bovine hip joint is distinctly different. Based on this study's data, the baboon represents the most appropriate animal model of normal human hip articular cartilage.
在狒狒、狗和牛的股骨头与髋臼中测定了正常成年关节软骨的材料特性，并与正常人类髋关节软骨的特性进行了比较。使用自动蠕变压痕装置进行了原位蠕变和恢复压痕实验。为了对整个蠕变曲线进行曲线拟合，开发了一种基于双相有限元方法和非线性优化的数值算法。这项工作代表了首次成功地利用100%的蠕变压痕曲线来获取正常关节软骨的力学性能。结果表明，关节软骨的材料特性在股骨头和髋臼以及这两个骨结构之间呈现出显著的地形变化。此外，这4个物种的髋关节软骨力学性能存在显著差异。具体而言，在所有物种中，股骨头下方的聚集模量最小。在所有测试部位，人类髋关节软骨在所有物种中最硬；牛组织最软。在所有测试部位，人类组织的泊松比和渗透率最小。狒狒髋关节软骨的聚集模量与人类髋关节软骨的聚集模量非常相似。在解剖学上，犬类和狒狒的髋关节与人类髋关节表现出相似的特征；牛髋关节则明显不同。基于这项研究的数据，狒狒代表了正常人类髋关节软骨最合适的动物模型。
