Vrensen G F
Department of Morphology, The Netherlands Ophthalmic Research Institute, Amsterdam.
Doc Ophthalmol. 1994;88(3-4):255-61. doi: 10.1007/BF01203679.
Experimental studies in mice and rats have shown that UV (B) irradiation leads to specific lens changes, viz. yellowing of the nucleus and a multilayered epithelium in the anterior pole with disrupted cortical fibres underneath. Biomicroscopic and ultrastructural studies on ageing human lenses revealed yellowing of the lens nucleus and locally ruptured membranes and small opacities in the equatorial cortex. No changes in the anterior pole were ever observed. This discrepancy between the human and animal lens, contraindicating UV as an important risk factor for human cataract, is discussed and may be due to several factors: (1) a difference between the high level acute and low level chronic irradiation; (2) species differences: nocturnal animals may be unable to cope with bright light exposure; (3) differences in scavenger and other defense mechanisms between humans and animals.
对小鼠和大鼠的实验研究表明，紫外线（B）照射会导致晶状体出现特定变化，即晶状体核变黄以及前极出现多层上皮，其下方的皮质纤维遭到破坏。对老化人晶状体的生物显微镜检查和超微结构研究显示，晶状体核变黄，赤道皮质局部膜破裂且出现小混浊。从未观察到前极有变化。讨论了人与动物晶状体之间的这种差异，这与紫外线是人类白内障的重要危险因素这一观点相悖，可能是由几个因素导致的：（1）高剂量急性照射和低剂量慢性照射之间的差异；（2）物种差异：夜行性动物可能无法应对强光照射；（3）人与动物在清除剂和其他防御机制方面的差异。
