埃可病毒12型的感染性cDNA克隆以及一种对脱壳抑制剂罗丹宁具有抗性的变体在七个氨基酸上存在差异。
Infectious cDNA clones of echovirus 12 and a variant resistant against the uncoating inhibitor rhodanine differ in seven amino acids.
作者信息
Kraus W, Zimmermann H, Zimmermann A, Eggers H J, Nelsen-Salz B
机构信息
Institut für Virologie, Universität zu Köln, Germany.
出版信息
J Virol. 1995 Sep;69(9):5853-8. doi: 10.1128/JVI.69.9.5853-5858.1995.
Abstract
Determination of the complete sequences of echovirus 12 and a rhodanine-resistant variant revealed seven amino acid deviations and two additional exchanges not confirmed in all clones. In rhodanine sensitivity assays with infectious cDNAs, it was shown that the biological markers of the original viruses are maintained.
摘要
埃可病毒12型和一种若丹宁抗性变体的完整序列测定揭示了七个氨基酸偏差以及两个在所有克隆中未得到确认的额外交换。在用感染性cDNA进行的若丹宁敏感性试验中，结果表明原始病毒的生物学标记得以保留。
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