• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Infectious cDNA clones of echovirus 12 and a variant resistant against the uncoating inhibitor rhodanine differ in seven amino acids.埃可病毒12型的感染性cDNA克隆以及一种对脱壳抑制剂罗丹宁具有抗性的变体在七个氨基酸上存在差异。
J Virol. 1995 Sep;69(9):5853-8. doi: 10.1128/JVI.69.9.5853-5858.1995.
2
Rhodanine resistance and dependence of echovirus 12: a possible consequence of capsid flexibility.埃可病毒12对若丹宁的抗性与依赖性：衣壳灵活性的可能结果
J Virol. 1997 Feb;71(2):1697-702. doi: 10.1128/JVI.71.2.1697-1702.1997.
3
Echovirus 5: infectious transcripts and complete nucleotide sequence from uncloned cDNA.
Virus Res. 1999 Jan;59(1):75-87. doi: 10.1016/s0168-1702(98)00127-0.
4
Genetic variability within the VP1 coding region of echovirus type 30 isolates.30型艾柯病毒分离株VP1编码区域内的基因变异性。
Arch Virol. 2000;145(7):1455-64. doi: 10.1007/s007050070102.
5
An infectious cDNA copy of the genome of a non-cardiovirulent coxsackievirus B3 strain: its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses.一种非心脏毒性柯萨奇病毒B3株基因组的感染性cDNA拷贝：其完整序列分析及与心脏毒性柯萨奇病毒基因组的比较
Arch Virol. 1994;135(1-2):115-30. doi: 10.1007/BF01309769.
6
Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis.柯萨奇B3病毒蛋白2B疏水结构域的遗传分析：病毒RNA合成中的顺式作用功能需要一定程度的疏水性。
J Virol. 1995 Dec;69(12):7782-90. doi: 10.1128/JVI.69.12.7782-7790.1995.
7
A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3.柯萨奇病毒B3伍德拉夫变种感染性cDNA的VP2 puff区域突变减弱了其心肌炎性表型。
J Virol. 1996 Nov;70(11):7811-8. doi: 10.1128/JVI.70.11.7811-7818.1996.
8
Complete sequence of echovirus 23 and its relationship to echovirus 22 and other human enteroviruses.埃可病毒23的完整序列及其与埃可病毒22和其他人类肠道病毒的关系。
Virus Res. 1998 Aug;56(2):217-23. doi: 10.1016/s0168-1702(98)00080-x.
9
Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment.柯萨奇病毒B3实验室菌株和临床分离株对衣壳功能抑制剂普来可那立的敏感性：病毒嵌合体的抗病毒研究证明了1092位氨基酸在治疗中的关键作用。
J Antimicrob Chemother. 2005 Oct;56(4):648-56. doi: 10.1093/jac/dki263. Epub 2005 Sep 8.
10
Dependence of echovirus 9 on the enterovirus RNA replication inhibitor 2-(alpha-Hydroxybenzyl)-benzimidazole maps to nonstructural protein 2C.埃可病毒9对肠道病毒RNA复制抑制剂2 -（α-羟基苄基）-苯并咪唑的依赖性定位于非结构蛋白2C。
J Virol. 1999 Dec;73(12):10536-9. doi: 10.1128/JVI.73.12.10536-10539.1999.

引用本文的文献

1
Molecular characterization of echovirus 12 strains isolated from healthy children in China.中国健康儿童分离的肠道病毒 12 型的分子特征。
Sci Rep. 2018 Aug 6;8(1):11716. doi: 10.1038/s41598-018-30250-x.
2
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.人鼻病毒3C蛋白酶中氨基酸的保守性与新型人鼻病毒3C蛋白酶抑制剂鲁平替尼的广谱抗病毒活性相关。
Antimicrob Agents Chemother. 2005 Feb;49(2):619-26. doi: 10.1128/AAC.49.2.619-626.2005.
3
A predicted secondary structural domain within the internal ribosome entry site of echovirus 12 mediates a cell-type-specific block to viral replication.12型埃可病毒内部核糖体进入位点内的一个预测二级结构域介导了对病毒复制的细胞类型特异性阻断。
J Virol. 2001 Jul;75(14):6472-81. doi: 10.1128/JVI.75.14.6472-6481.2001.
4
Mutations in the 2C region of poliovirus responsible for altered sensitivity to benzimidazole derivatives.脊髓灰质炎病毒2C区域的突变与对苯并咪唑衍生物敏感性改变有关。
J Virol. 2000 May;74(9):4146-54. doi: 10.1128/jvi.74.9.4146-4154.2000.
5
Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification.人类肠道病毒的分子进化：血清型与VP1序列的相关性及其在小RNA病毒分类中的应用
J Virol. 1999 Mar;73(3):1941-8. doi: 10.1128/JVI.73.3.1941-1948.1999.
6
Molecular typing of enteroviruses: current status and future requirements. The European Union Concerted Action on Virus Meningitis and Encephalitis.肠道病毒的分子分型：现状与未来需求。欧盟病毒性脑膜炎和脑炎联合行动。
Clin Microbiol Rev. 1998 Jan;11(1):202-27. doi: 10.1128/CMR.11.1.202.
7
Rhodanine resistance and dependence of echovirus 12: a possible consequence of capsid flexibility.埃可病毒12对若丹宁的抗性与依赖性：衣壳灵活性的可能结果
J Virol. 1997 Feb;71(2):1697-702. doi: 10.1128/JVI.71.2.1697-1702.1997.
8
Molecular cloning and sequence determination of the complete genome of the virulent echovirus 9 strain barty.强毒株埃可病毒9型巴蒂株全基因组的分子克隆与序列测定
Virus Genes. 1996;12(2):149-54. doi: 10.1007/BF00572953.

本文引用的文献

1
HPLC is an effective and fast method for analysis of viral proteins: a study of encephalomyocarditis virus mutants differing in pathogenicity.
J Gen Virol. 1993 Dec;74 ( Pt 12):2759-63. doi: 10.1099/0022-1317-74-12-2759.
2
Rhodanine: a selective inhibitor of the multiplication of echovirus 12.
Science. 1970 Jan 16;167(3916):294-7. doi: 10.1126/science.167.3916.294.
3
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating.人鼻病毒14中抑制脱壳的抗病毒药物的附着位点。
Science. 1986 Sep 19;233(4770):1286-93. doi: 10.1126/science.3018924.
4
Human rhinovirus 14 complexed with antiviral compound R 61837.与抗病毒化合物R 61837复合的人鼻病毒14
J Mol Biol. 1991 Feb 5;217(3):455-63. doi: 10.1016/0022-2836(91)90749-v.
5
Selective inhibiton of uncoating of echovirus 12 by rhodanine. A study on early virus-cell interactions.罗丹宁对艾柯病毒12脱壳的选择性抑制作用。早期病毒与细胞相互作用的研究。
Virology. 1977 May 1;78(1):241-52. doi: 10.1016/0042-6822(77)90095-2.

埃可病毒12型的感染性cDNA克隆以及一种对脱壳抑制剂罗丹宁具有抗性的变体在七个氨基酸上存在差异。

Infectious cDNA clones of echovirus 12 and a variant resistant against the uncoating inhibitor rhodanine differ in seven amino acids.

作者信息

Kraus W, Zimmermann H, Zimmermann A, Eggers H J, Nelsen-Salz B

机构信息

Institut für Virologie, Universität zu Köln, Germany.

出版信息

J Virol. 1995 Sep;69(9):5853-8. doi: 10.1128/JVI.69.9.5853-5858.1995.

DOI:10.1128/JVI.69.9.5853-5858.1995
PMID:7637032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189459/
Abstract

Determination of the complete sequences of echovirus 12 and a rhodanine-resistant variant revealed seven amino acid deviations and two additional exchanges not confirmed in all clones. In rhodanine sensitivity assays with infectious cDNAs, it was shown that the biological markers of the original viruses are maintained.

摘要

埃可病毒12型和一种若丹宁抗性变体的完整序列测定揭示了七个氨基酸偏差以及两个在所有克隆中未得到确认的额外交换。在用感染性cDNA进行的若丹宁敏感性试验中，结果表明原始病毒的生物学标记得以保留。