人类免疫缺陷病毒在精液中的间歇性排出：对性传播的影响。
Intermittent shedding of human immunodeficiency virus in semen: implications for sexual transmission.
作者信息
Krieger J N, Coombs R W, Collier A C, Ho D D, Ross S O, Zeh J E, Corey L
机构信息
Department of Urology, Medicine and Statistics, University of Washington, Seattle, USA.
出版信息
J Urol. 1995 Sep;154(3):1035-40.
PURPOSE
We attempt to increase our understanding of human immunodeficiency virus (HIV) shedding in semen.
MATERIALS AND METHODS
We followed 16 seropositive men for up to 27 months by HIV cocultivation, with a subset evaluated using the polymerase chain reaction.
RESULTS
The proportion with at least 1 HIV positive semen culture increased from 3 of 16 subjects (19%) at visit 1 to 10 (63%) by visit 5. Overall, HIV was cultured from 25 of 114 specimens (22%). Shedding was intermittent for each of the 10 men with at least 1 positive culture and seminal shedding patterns were highly variable.
CONCLUSIONS
By culture and polymerase chain reaction, HIV is shed intermittently in the semen. If cultures are performed often enough most seropositive men shed HIV in the semen.
目的
我们试图增进对人类免疫缺陷病毒（HIV）在精液中排出情况的了解。
材料与方法
我们通过HIV共培养对16名血清反应阳性的男性进行了长达27个月的随访，其中一部分人使用聚合酶链反应进行了评估。
结果
至少有1次HIV阳性精液培养的比例从第1次访视时16名受试者中的3名（19%）增加到第5次访视时的10名（63%）。总体而言，114份标本中有25份（22%）培养出HIV。对于10名至少有1次阳性培养的男性，病毒排出是间歇性的，精液排出模式高度可变。
结论
通过培养和聚合酶链反应，HIV在精液中呈间歇性排出。如果进行足够频繁的培养，大多数血清反应阳性男性的精液中会排出HIV。
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