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[不同溶剂对取自工作环境的空气尘埃遗传毒性研究结果的影响]

[Impact of different solvents on results of genotoxicity studies of airborne dust taken from work environments].

作者信息

Mielzyńska D, Siwińska E, Smolik E, Szaciłło H

机构信息

Z Zakładu Toksykologii, Instytutu Medycyny Pracy i Zdrowia Srodowiskowego w Sosnowcu.

出版信息

Med Pr. 1995;46(2):161-8.

PMID:7637635
Abstract

Mutagenicity and toxicity of extracts of airborne particulate matters, sampled during electrolysis of aluminium, cooking of coal and low-temperature carbonization processes, were determined by the Salmonella plate incorporation assay with strains TA98 and TA100. Organic materials were extracted with benzene, cyclohexane or toluene from airborne particles by sonication. The results showed that: a) the extracts were mutagenic only to strain TA98 (without and after metabolic activation); b) there was a similar efficiency of applied solvents in extraction of mutagenic substances detectable with TA98, and c) the toluene extracts were most toxic towards test bacteria TA98.

摘要

采用鼠伤寒沙门氏菌TA98和TA100菌株平板掺入法,测定了在铝电解、煤炭燃烧和低温碳化过程中采集的空气颗粒物提取物的致突变性和毒性。通过超声处理,用苯、环己烷或甲苯从空气颗粒中提取有机物质。结果表明:a)提取物仅对TA98菌株具有致突变性(无论有无代谢活化);b)对于用TA98可检测到的诱变物质,所用溶剂的提取效率相似;c)甲苯提取物对测试细菌TA98的毒性最大。

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