Hendricks G L, Mashaly M M, Siegel H S
Department of Poultry Science, Pennsylvania State University, University Park 16802, USA.
Proc Soc Exp Biol Med. 1995 Sep;209(4):382-6. doi: 10.3181/00379727-209-43911.
Corticotropin releasing factor (CRF) and corticosterone have been shown to affect immune cell function. Previously, we have shown that CRF stimulates immunoreactive adrenocorticotropic hormone (ACTH) production by leukocytes. In this study, splenic leukocytes from corticosterone-injected chickens failed to show a CRF-induced increase in ACTH production. In addition, corticosterone in vitro inhibited the production of leukocyte ACTH as well as the stimulatory effect of CRF on splenic leukocyte ACTH production. These findings show that, as with anterior pituitary ACTH production, CRF-stimulated leukocyte ACTH production is inhibited by glucocorticoids.
促肾上腺皮质激素释放因子（CRF）和皮质酮已被证明会影响免疫细胞功能。此前，我们已经表明CRF可刺激白细胞产生免疫反应性促肾上腺皮质激素（ACTH）。在本研究中，注射皮质酮的鸡的脾脏白细胞未表现出CRF诱导的ACTH产生增加。此外，体外皮质酮抑制白细胞ACTH的产生以及CRF对脾脏白细胞ACTH产生的刺激作用。这些发现表明，与垂体前叶ACTH产生一样，糖皮质激素会抑制CRF刺激的白细胞ACTH产生。
