Nelson D A, Jacobsen G, Barondess D A, Parfitt A M
Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.
J Bone Miner Res. 1995 May;10(5):782-7. doi: 10.1002/jbmr.5650100515.
There are few published data on bone mass, measured by dual-energy X-ray absorptiometry (DXA), in healthy white or black men. Similarly, a recently described predictor of hip fracture among white women, hip axis length (HAL), has not been studied in men. We recruited 160 white and 34 black men, aged 23-80 years, and screened for diseases and drug exposures that adversely affect skeletal health. We measured bone mineral density (BMD) in the lumbar spine, femoral neck, and radial shaft by DXA; height and weight; skin color by reflectometry; and hip axis length both directly from DXA output and using automated software in a subsample. We also obtained historical data on education, smoking, exercise, and fractures. There were no significant black/white differences in mean weight, height, body mass index (BMI), or HAL. The black men had higher BMDs than did the white men at every site (5% for the radius, 10% for the lumbar spine, and 20% for the femoral neck). Skin pigmentation and BMD were not significantly correlated in either group (p > 0.38). Among the white men, smoking was associated with lower lumbar BMD, but there was no significant relationship between BMD and exercise frequency in either group. There was no significant ethnic difference in fracture experience. We conclude that: (1) the higher BMD in black men than in white men is not due to greater body size, (2) the lower hip fracture risk reported for black men than for white men is not due to a difference in hip axis length; (3) skin color is not related to BMD in either sex.
关于通过双能X线吸收法（DXA）测量的健康白人或黑人男性骨量的已发表数据很少。同样，最近描述的白人女性髋部骨折预测指标——髋轴长度（HAL），尚未在男性中进行研究。我们招募了160名年龄在23 - 80岁之间的白人和34名黑人男性，并对影响骨骼健康的疾病和药物暴露情况进行了筛查。我们通过DXA测量了腰椎、股骨颈和桡骨干的骨密度（BMD）；测量了身高和体重；通过反射法测量了肤色；并直接从DXA输出结果以及在一个子样本中使用自动化软件测量了髋轴长度。我们还获取了有关教育、吸烟、运动和骨折的历史数据。在平均体重、身高、体重指数（BMI）或HAL方面，黑人和白人之间没有显著差异。黑人男性在每个部位的骨密度均高于白人男性（桡骨高5%，腰椎高10%，股骨颈高20%）。两组中皮肤色素沉着与骨密度均无显著相关性（p>0.38）。在白人男性中，吸烟与较低的腰椎骨密度相关，但两组中骨密度与运动频率之间均无显著关系。骨折经历方面没有显著的种族差异。我们得出以下结论：（1）黑人男性比白人男性更高的骨密度并非由于体型更大；（2）报告的黑人男性比白人男性更低的髋部骨折风险并非由于髋轴长度的差异；（3）肤色在两性中均与骨密度无关。
