Stain S C, Guthrie C R, Yellin A E, Donovan A J
Department of Surgery, University of Southern California, School of Medicine, Los Angeles, USA.
Ann Surg. 1995 Aug;222(2):128-33. doi: 10.1097/00000658-199508000-00004.
The authors examined the natural history of choledochal cysts in adults treated surgically.
An initial diagnosis of choledochal cyst is uncommon in adults. The recommended treatment is excision, rather than bypass, to achieve effective biliary drainage and because of the risk of cancer.
A retrospective study of 27 adult patients was completed to determine the frequency of anastomotic complications and the incidence of cancer.
Fifteen patients were treated by cyst excision, and one developed an anastomotic stricture, treated by percutaneous dilation. Eight of 11 patients treated by cyst enterostomy required additional surgery for anastomotic revision. A final patient was treated by T-tube drainage. Five of the seven patients with cancer have died at a mean of 21.6 months.
This experience documents the high incidence of cancer (26%), and high rate of stricture after cyst enterostomy (73%). The dismal prognosis once cancer has developed warrants cyst excision, even in asymptomatic patients, including those with prior cyst enterostomies.
作者研究了接受手术治疗的成人胆总管囊肿的自然病史。
成人胆总管囊肿的初始诊断并不常见。推荐的治疗方法是切除而非旁路手术,以实现有效的胆汁引流并降低癌症风险。
完成了一项对27例成年患者的回顾性研究,以确定吻合口并发症的发生率和癌症的发病率。
15例患者接受了囊肿切除术,其中1例出现吻合口狭窄,经皮扩张治疗。11例接受囊肿肠造口术的患者中有8例需要再次手术进行吻合口修复。最后1例患者接受了T管引流。7例癌症患者中有5例已死亡,平均存活时间为21.6个月。
该研究记录了癌症的高发病率(26%)和囊肿肠造口术后狭窄的高发生率(73%)。一旦发生癌症,预后不佳,即使是无症状患者,包括既往接受过囊肿肠造口术的患者,也应进行囊肿切除术。