Leiferman K M
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Semin Dermatol. 1995 Jun;14(2):122-8. doi: 10.1016/s1085-5629(05)80007-0.
The hypereosinophilic syndrome is a multisystem syndrome characterized by peripheral blood eosinophilia and eosinophil infiltration of bone marrow, heart, and other organs. The syndrome is associated with cardiac, hematological, pulmonary, neurological, and cutaneous involvement and, if untreated, has a high fatality rate. Criteria for the diagnosis of hypereosinophilic syndrome include (1) peripheral blood eosinophilia with eosinophil counts greater than 1,500/microL for at least 6 months; (2) no evidence of parasitic, allergic, or other known causes of eosinophilia; and (3) presumptive signs and symptoms of multiple organ involvement. Cutaneous manifestations occur commonly but are not diagnostic either clinically or histologically, although the presence of angioedema is a favorable prognostic sign. Because eosinophils are thought to mediate important pathogenic effects, treatment is aimed at controlling peripheral blood eosinophilia.
高嗜酸性粒细胞综合征是一种多系统综合征，其特征为外周血嗜酸性粒细胞增多以及骨髓、心脏和其他器官的嗜酸性粒细胞浸润。该综合征与心脏、血液、肺部、神经和皮肤受累有关，若不治疗，病死率很高。高嗜酸性粒细胞综合征的诊断标准包括：（1）外周血嗜酸性粒细胞增多，嗜酸性粒细胞计数至少6个月大于1500/微升；（2）无寄生虫、过敏或其他已知嗜酸性粒细胞增多原因的证据；（3）多器官受累的推测性体征和症状。皮肤表现常见，但在临床或组织学上均无诊断意义，尽管血管性水肿的存在是一个良好的预后标志。由于嗜酸性粒细胞被认为介导重要的致病作用，治疗旨在控制外周血嗜酸性粒细胞增多。
