Kostopoulos L, Karring T, Uraguchi R
Department of Periodontology and Oral Gerontology, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark.
Clin Oral Implants Res. 1994 Dec;5(4):245-53. doi: 10.1034/j.1600-0501.1994.050408.x.
The aim of this study was to explore the possibility of creating bone tuberosities on the mandibular ramus in rats, using a rigid, occlusive, Teflon capsule. The experiment was carried out in 30 rats. The mandibular ramus was exposed bilaterally. On the test side, the periosteum was left covering the lateral surface of the ramus. On the contralateral side (control), the periosteum was elevated from the lateral surface together with the flap. A hemispherical, Teflon capsule was then placed to face the periosteum or the bone surface with its open part before closure of the wound. The healing periods comprised 7-120 days. Histological analysis demonstrated increasing bone fill in the test specimens from 7 to 60 days, and a limited further increase was observed from 60 to 120 days. In the control specimens, limited bone fill was seen within the first month after surgery, but substantial amounts of new bone were produced from 30-120 days. At 120 days, the mean amount of bone obtained in the test specimens was 56% (range 39%-71%) of the total space created by the capsules, and it was 52% (range 32%-85%) in the controls. The amount of newly formed bone was equivalent to a 5-6 times increase of the original width of the mandibular ramus. These findings indicate that a secluded space created by an occlusive barrier adjacent to existing bone or periosteum may be filled out with bone tissue. This may have a great clinical impact in cranial and maxillofacial surgery.
本研究的目的是探讨使用一种刚性、封闭的聚四氟乙烯胶囊在大鼠下颌支上制造骨隆突的可能性。实验在30只大鼠身上进行。双侧暴露下颌支。在测试侧，保留骨膜覆盖下颌支的外侧表面。在对侧（对照组），将骨膜连同皮瓣一起从外侧表面掀起。然后在伤口闭合前，放置一个半球形聚四氟乙烯胶囊，使其开口部分面向骨膜或骨表面。愈合期为7至120天。组织学分析表明，测试标本中的骨填充在7至60天内增加，在60至120天内观察到有限的进一步增加。在对照标本中，术后第一个月内可见有限的骨填充，但在30至120天内产生了大量新骨。在120天时，测试标本中获得的骨平均量为胶囊所创造总空间的56%（范围为39% - 71%），对照组为52%（范围为32% - 85%）。新形成的骨量相当于下颌支原始宽度增加了5至6倍。这些发现表明，由与现有骨或骨膜相邻的封闭屏障所创造的隐蔽空间可能会被骨组织填充。这可能在颅颌面外科手术中具有重大的临床意义。
