Taioli E, Trachman J, Chen X, Toniolo P, Garte S J
Institute of Environmental Medicine, New York University Medical Center, NY 10010, USA.
Cancer Res. 1995 Sep 1;55(17):3757-8.
We examined the role of CYP1A1 polymorphisms as potential molecular markers of breast cancer susceptibility in Caucasian and African-American women. The case-control study involved 51 women with breast cancer and 269 female controls. In African-Americans, the frequency of the homozygous MspI polymorphism was 3.5% in controls and 19% in breast cancer cases. The odds ratio of breast cancer with the MspI homozygous variant was 9.7 (95% confidence interval: 2.0-47.9). This association was not observed in Caucasian women. The exon 7 and AA polymorphisms were not associated with breast cancer in either group. The mechanism for the observed association between the MspI polymorphism and breast cancer is unclear. It is possible that the CYP1A1 MspI RFLP is linked with other polymorphisms in the African-American population, either in the CYP1A1 gene, which is involved in estrogen metabolism, or other genes related to risk of breast cancer.
我们研究了CYP1A1基因多态性作为白种人和非裔美国女性乳腺癌易感性潜在分子标志物的作用。这项病例对照研究涉及51名乳腺癌女性患者和269名女性对照。在非裔美国人中，纯合MspI多态性在对照中的频率为3.5%，在乳腺癌病例中为19%。携带MspI纯合变异的乳腺癌的优势比为9.7（95%置信区间：2.0 - 47.9）。在白种女性中未观察到这种关联。外显子7和AA多态性在两组中均与乳腺癌无关。MspI多态性与乳腺癌之间观察到的关联机制尚不清楚。有可能CYP1A1 MspI限制性片段长度多态性与非裔美国人群中的其他多态性相关联，要么在参与雌激素代谢的CYP1A1基因中，要么在与乳腺癌风险相关的其他基因中。
